Arsenic level in toenails is associated with hearing loss in humans.
Arsenic level in toenails is associated with hearing loss in humans.
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DOI：
10.1371/journal.pone.0198743
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Kato M
中科院分区：
文献类型：
--
作者：
Li X;Ohgami N;Yajima I;Xu H;Iida M;Oshino R;Ninomiya H;Shen D;Ahsan N;Akhand AA;Kato M
饮用水中的砷（As）污染对人类的健康是一个全球性的风险。我们以前曾在生活在砷污染的饮用水地区的年轻人和口服砷的年轻小鼠中发现听力损失。在这项研究中，我们在2014年对145名12-55岁的孟加拉国人的脚趾甲中的砷水平与听力之间的关系进行了流行病学研究。结果表明，在4 kHz、8 kHz和10 kHz频率下，趾甲中的As水平与听力损失显著相关，而尿中的As水平与听力损失无关[比值比（OR）= 4.27; 95%置信区间（CI）：1.51，12.05]。（OR = 3.91; 95% CI：1.47，10.38）和12 kHz（OR = 4.15; 95% CI：1.55，11.09）进行多变量分析，调整了年龄、性别、吸烟和BMI。经口砷暴露小鼠内耳砷含量与指甲砷含量呈显著正相关（r = 0.8113，p = 0.0014），提示指甲砷含量可作为评价内耳砷含量的指标。总之，我们的研究结果表明，指甲中的砷水平可能是一个方便和非侵入性的生物标志物作为介导的人类听力损失。
Arsenic (As) pollution in drinking water is a worldwide health risk for humans. We previously showed hearing loss in young people who live in areas of As-polluted drinking water and in young mice orally treated with As. In this study, we epidemiologically examined associations between As levels in toenails and hearing in 145 Bangladeshi aged 12–55 years in 2014. Levels of As in toenails, but not those in urine, were shown to be significantly correlated with hearing loss at 4 kHz [odds ratio (OR) = 4.27; 95% confidence interval (CI): 1.51, 12.05], 8 kHz (OR = 3.91; 95% CI: 1.47, 10.38) and 12 kHz (OR = 4.15; 95% CI: 1.55, 11.09) by multivariate analysis with adjustments for age, sex, smoking and BMI. Our experimental study further showed a significant association between As levels in inner ears and nails (r = 0.8113, p = 0.0014) in mice orally exposed to As, suggesting that As level in nails is a suitable index to assess As level in inner ears. Taken together, the results of our study suggest that As level in nails could be a convenient and non-invasive biomarker for As-mediated hearing loss in humans.
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DOI：
10.1186/s12940-016-0127-y
发表时间：
2016-03-12
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Rodrigues EG;Bellinger DC;Valeri L;Hasan MO;Quamruzzaman Q;Golam M;Kile ML;Christiani DC;Wright RO;Mazumdar M
通讯作者：
Mazumdar M
影响因子：
4.6
作者：
Ohgami N;Yajima I;Iida M;Li X;Oshino R;Kumasaka MY;Kato M
通讯作者：
Kato M
影响因子：
8.3
作者：
Coronado-Gonzalez, Jose Antonio;Del Razo, Luz Maria;la Pena, Jorge Escobedo-de
通讯作者：
la Pena, Jorge Escobedo-de
影响因子：
5.4
作者：
Schisterman, EF;Perkins, NJ;Bondell, H
通讯作者：
Bondell, H
影响因子：
5
作者：
Kim, Nan Hee;Mason, Clinton C.;Sandler, Dale P.
通讯作者：
Sandler, Dale P.