Maternal care boosted by paternal imprinting in mammals.
Maternal care boosted by paternal imprinting in mammals.
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哺乳动物的父系印记促进了母性护理。
DOI：
10.1371/journal.pbio.2006599
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发表时间：
2018-07
期刊：
影响因子：
9.8
通讯作者：
John RM
中科院分区：
文献类型：
--
作者：
Creeth HDJ;McNamara GI;Tunster SJ;Boque-Sastre R;Allen B;Sumption L;Eddy JB;Isles AR;John RM
在哺乳动物中，母亲是主要的照顾者，部分是由怀孕期间产生的激素决定的。高质量的孕产妇护理对后代的生存和终身健康至关重要。我们以前表明，父系沉默的印迹基因pleckstrin同源样结构域家族A成员2（Phlda 2）的功能，负调控一个单一的谱系在小鼠胎盘称为海绵滋养层，在怀孕的激素的主要来源。因此，后代的Phlda 2基因剂量可能会影响母亲提供的护理质量。在这里，我们表明，野生型（WT）雌性小鼠暴露于后代与三种不同剂量的母体表达的Phlda 2基因-两个活跃的等位基因，一个活跃的等位基因（现存状态），和功能的丧失-显示在怀孕期间，在母体下丘脑和海马体的变化，该地区的重要母性护理行为。出生后，在子宫内暴露于具有最高Phlda 2剂量的后代的WT母鼠表现出对幼崽的护理和梳理减少，并且对筑巢的关注增加。相反，暴露于最低Phlda 2剂量的“家长化”母鼠表现出对幼崽的养育增加，自我导向行为增加，对筑巢的关注减少，这种行为在没有转基因幼崽的情况下得到了有力的维持。这项工作提出了一种有趣的可能性，即Phlda 2的印记有助于在哺乳动物进化过程中增加母性关怀。雌性哺乳动物在怀孕期间为她们作为照顾新生儿的母亲的新角色做好准备。间接证据表明，这种行为部分是由胎儿胎盘产生的激素指示的。我们以前报道过Phlda 2基因控制产生激素的胎盘内分泌室的大小。Phlda 2受到称为基因组印记的显着表观遗传过程的影响，其中一个亲本等位基因被关闭。在Phlda 2的情况下，这是父系等位基因。这提出了一个有趣的可能性，即父亲的基因组影响后代从母亲那里得到的照顾的质量。在这里，我们通过对幼鼠胚胎的遗传操作表明，怀上携带最高剂量Phlda 2的幼鼠的雌性小鼠更喜欢筑巢，而不是照顾它们的幼崽或自己。相比之下，怀孕时暴露于最低Phlda 2剂量的母鼠优先考虑养育和梳理其幼仔和个人梳理。这些变化表明，母亲的重点印迹Phlda 2的可能性，有助于提高哺乳动物的孕产妇保健。这项研究还提供了一个独特的例子，说明后代的基因构成如何影响母亲的行为。
In mammals, mothers are the primary caregiver, programmed, in part, by hormones produced during pregnancy. High-quality maternal care is essential for the survival and lifelong health of offspring. We previously showed that the paternally silenced imprinted gene pleckstrin homology-like domain family A member 2 (Phlda2) functions to negatively regulate a single lineage in the mouse placenta called the spongiotrophoblast, a major source of hormones in pregnancy. Consequently, the offspring’s Phlda2 gene dosage may influence the quality of care provided by the mother. Here, we show that wild-type (WT) female mice exposed to offspring with three different doses of the maternally expressed Phlda2 gene—two active alleles, one active allele (the extant state), and loss of function—show changes in the maternal hypothalamus and hippocampus during pregnancy, regions important for maternal-care behaviour. After birth, WT dams exposed in utero to offspring with the highest Phlda2 dose exhibit decreased nursing and grooming of pups and increased focus on nest building. Conversely, ‘paternalised’ dams, exposed to the lowest Phlda2 dose, showed increased nurturing of their pups, increased self-directed behaviour, and a decreased focus on nest building, behaviour that was robustly maintained in the absence of genetically modified pups. This work raises the intriguing possibility that imprinting of Phlda2 contributed to increased maternal care during the evolution of mammals. Female mammals are primed during pregnancy for their new role as a mother caring for their newborn. Indirect evidence suggests that this behaviour is, in part, instructed by hormones produced by the foetally derived placenta. We previously reported that the Phlda2 gene controls the size of the placental endocrine compartment that produces hormones. Phlda2 is subject to the remarkable epigenetic process called genomic imprinting, in which one parental allele is switched off. In the case of Phlda2, this is the paternal allele. This raises the intriguing possibility that the father’s genome influences the quality of care that offspring receive from their mothers. Here, we show via genetic manipulation of pup embryos that female mice pregnant with pups carrying the highest dose of Phlda2 favour nest building over caring for their young or themselves. In contrast, dams exposed to the lowest Phlda2 dose while pregnant prioritise nurturing and grooming of their young and personal grooming. These changes in maternal focus suggest the possibility that imprinting of Phlda2 contributed to enhanced maternal care in mammals. This study also presents a unique example of how the genetic makeup of offspring can influence maternal behaviour.
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DOI：
10.1073/pnas.0807412105
发表时间：
2008-11-04
影响因子：
11.1
作者：
Bosch, Oliver J.;Neumann, Inga D.
通讯作者：
Neumann, Inga D.
影响因子：
--
作者：
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通讯作者：
Linzer, DIH
影响因子：
2.2
作者：
DEVITERNE, D;DESOR, D
通讯作者：
DESOR, D
影响因子：
4.1
作者：
Bridges, RS;Robertson, MC;Mann, PE
通讯作者：
Mann, PE
影响因子：
7
作者：
Draghici, Sorin;Khatri, Purvesh;Romero, Roberto
通讯作者：
Romero, Roberto