Cancer Prevention and Therapy with Polyphenols: Sphingolipid-Mediated Mechanisms.
Cancer Prevention and Therapy with Polyphenols: Sphingolipid-Mediated Mechanisms.
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DOI：
10.3390/nu10070940
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发表时间：
2018-07-21
期刊：
影响因子：
5.9
通讯作者：
Ghidoni R
中科院分区：
文献类型：
--
作者：
Dei Cas M;Ghidoni R
多酚的化学特征是多羟基化的酚结构，其广泛的药理学性质是众所周知的：抗炎、抗生素、防腐剂、抗肿瘤、抗过敏、心脏保护等。它们在食品中的分布也很广泛，特别是在蔬菜、谷物、豆类、水果、坚果和某些饮料等植物性食品中。最新的科学文献概述了通过鞘脂介导的机制，癌症调节和膳食多酚之间的弹性相互关系，通常与其代谢的改变相关。我们的目标是广泛调查这种关系，以显示它如何在癌症治疗或预防营养素方面具有优势。从该分析中可以看出，经典化疗与营养素，特别是多酚膳食来源的组合可以提高疗效并减少化疗药物的负面副作用。在这种多方面的情况下，鞘脂作为生物活性分子发挥着关键作用，成为癌症细胞增殖的介质和化疗药物的调节剂。
Polyphenols, chemically characterized by a polyhydroxylated phenolic structure, are well known for their widespread pharmacological properties: anti-inflammatory, antibiotic, antiseptic, antitumor, antiallergic, cardioprotective and others. Their distribution in food products is also extensive especially in plant foods such as vegetables, cereals, legumes, fruits, nuts and certain beverages. The latest scientific literature outlines a resilient interconnection between cancer modulation and dietary polyphenols by sphingolipid-mediated mechanisms, usually correlated with a modification of their metabolism. We aim to extensively survey this relationship to show how it could be advantageous in cancer treatment or prevention by nutrients. From this analysis it emerges that a combination of classical chemotherapy with nutrients and especially with polyphenols dietary sources may improve efficacy and decreases negative side effects of the antineoplastic drug. In this multifaceted scenario, sphingolipids play a pivotal role as bioactive molecules, emerging as the mediators of cell proliferation in cancer and modulator of chemotherapeutics.
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影响因子：
5.6
作者：
D'Archivio M;Filesi C;Varì R;Scazzocchio B;Masella R
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