Involvement of GABA(A) Receptors in the Anxiolytic-Like Effect of Hydroxycitronellal.
Involvement of GABA(A) Receptors in the Anxiolytic-Like Effect of Hydroxycitronellal.
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DOI：
10.1155/2021/9929805
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发表时间：
2021
影响因子：
--
通讯作者：
Almeida RN
中科院分区：
文献类型：
--
作者：
Andrade JC;Monteiro ÁB;Andrade HHN;Gonzaga TKSN;Silva PR;Alves DN;Castro RD;Maia MS;Scotti MT;Sousa DP;Almeida RN
羟基香茅醛（HC）是存在于不同物种的芳香植物的精油中的单萜，由香茅醛的半合成获得，并且广泛用作化妆品中的香料。这项工作的目的是使用体内和计算机模拟方法评价HC可能的抗焦虑样活性及其可能的作用机制。将Swiss雄性小鼠（Mus musculus）用HC（12.5、25和50 mg/kg，i. p.）并进行旋转杆、高架十字迷宫和旷场测试。在12.5、25和50 mg/kg（i. p.）HC给药动物的旋转杆试验中，未观察到运动活动的显著损伤，表明没有肌肉松弛或镇静作用。在高架十字迷宫中，HC（三个剂量）诱导进入开放臂的百分比（分别为34.8%，33.8%和38.6%）和停留时间（分别为49.9%，56.1%和57.0%）以及在旷场测试中的交叉次数显著增加。该化合物的抗焦虑样活性的作用机制可归因于GABAA受体的参与，并且在体内和计算机模拟研究中观察到这种相互作用。对于HC，结果表明可能通过调节GABA能系统产生抗焦虑样作用。使用天然产品治疗焦虑症可以成为现有合成产品的替代品。
Hydroxycitronellal (HC) is a monoterpene present in essential oils of aromatic plants of different species, obtained from semisynthesis of citronellal, and is widely used as a fragrance in cosmetics. The objective of this work was to evaluate the possible anxiolytic-like activity of HC and its possible mechanism of action using in vivo and in silico methodologies. Swiss male mice (Mus musculus) were treated with HC (12.5, 25, and 50 mg/kg, i.p.) and subjected to the rota rod, elevated plus maze, and open field tests. No significant impairments were observed in the rota rod tests for the motor activity of the animals treated with HC at 12.5, 25, and 50 mg/kg, i.p., indicating no myo-relaxing or sedative effects. In the elevated plus maze, HC (in the three doses) induced significant increases in the percentage of entries (respectively, 34.8%, 33.8%, and 38.6%) and in the length of stay (respectively, 49.9%, 56.1%, and 57.0%) in the open arms of the EPM, as well as the number of crossings in the open field tests. The mechanism of action of the compound's anxiolytic-like activity can be attributed to the involvement of GABAA receptors, and this interaction was observed in in vivo and in silico studies. For HC, the results suggest anxiolytic-like effects, possibly via modulation of the GABAergic system. The use of natural products to treat anxiety can become an alternative to existing synthetic products.
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影响因子：
8.2
作者：
Choleris, E;Thomas, AW;Prato, FS
通讯作者：
Prato, FS
影响因子：
3.8
作者：
de Santana, Marilia Trindade;Brito de Oliveira, Makson Gleydson;Quintans-Junior, Lucindo Jose
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Quintans-Junior, Lucindo Jose
影响因子：
4.6
作者：
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影响因子：
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作者：
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通讯作者：
BONDI, A
影响因子：
6.3
作者：
BERENDSEN, HJC;VANDERSPOEL, D;VANDRUNEN, R
通讯作者：
VANDRUNEN, R