The star-nosed mole reveals clues to the molecular basis of mammalian touch.
The star-nosed mole reveals clues to the molecular basis of mammalian touch.
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DOI：
10.1371/journal.pone.0055001
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Bautista DM
中科院分区：
文献类型：
--
作者：
Gerhold KA;Pellegrino M;Tsunozaki M;Morita T;Leitch DB;Tsuruda PR;Brem RB;Catania KC;Bautista DM
很少有人知道哺乳动物触摸转导的分子机制。为了确定新的候选传感器，我们研究了动物王国中最敏感的触觉器官之一--星鼻鼹鼠的星星中触觉的分子和细胞基础。我们的研究结果表明，三叉神经节支配的星星是丰富的触觉敏感神经元，导致在较高比例的光触摸纤维和较低比例的伤害感受器相比，背根神经节支配身体的其余部分。我们利用这种差异，星鼻鼹鼠感觉神经节的转录组分析，以确定新的候选哺乳动物触摸和疼痛传感器。最丰富的候选人也在小鼠躯体感觉神经节中表达，这表明它们可能介导不同物种的转导，而不是鼹鼠所独有的。这些发现突出了检查不同和专门的物种来解决哺乳动物生物学中的基本问题的实用性。
Little is known about the molecular mechanisms underlying mammalian touch transduction. To identify novel candidate transducers, we examined the molecular and cellular basis of touch in one of the most sensitive tactile organs in the animal kingdom, the star of the star-nosed mole. Our findings demonstrate that the trigeminal ganglia innervating the star are enriched in tactile-sensitive neurons, resulting in a higher proportion of light touch fibers and lower proportion of nociceptors compared to the dorsal root ganglia innervating the rest of the body. We exploit this difference using transcriptome analysis of the star-nosed mole sensory ganglia to identify novel candidate mammalian touch and pain transducers. The most enriched candidates are also expressed in mouse somatosesensory ganglia, suggesting they may mediate transduction in diverse species and are not unique to moles. These findings highlight the utility of examining diverse and specialized species to address fundamental questions in mammalian biology.
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