Efficacy of Duhuo Jisheng Decoction for Treating Cold-Dampness Obstruction Syndrome-Type Knee Osteoarthritis: A Pooled Analysis.
Efficacy of Duhuo Jisheng Decoction for Treating Cold-Dampness Obstruction Syndrome-Type Knee Osteoarthritis: A Pooled Analysis.
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独活寄生汤治疗寒湿痹阻证型膝骨关节炎疗效的汇总分析
DOI：
10.1155/2022/2350404
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发表时间：
2022
影响因子：
--
通讯作者：
Liu, Jun
中科院分区：
文献类型：
--
作者：
Zhao, Jinlong;Liang, Guihong;Pan, Jianke;Yang, Weiyi;Zeng, Lingfeng;Liu, Jun
为独活寄生汤治疗寒湿痹阻型膝骨关节炎提供实验依据。 检索PubMed、Embase、科克伦图书馆、中国知网、万方数据库和中国生物医学文献库，以获得评价DHJSD或DHJSD联合其他常规疗法（DHJSD组）与常规疗法（对照组）治疗寒湿痹阻型KOA的随机对照试验（RCT）。我们使用固定或随机效应模型计算了合并比值比（OR）、平均差（MD）和95%置信区间（CI）。 纳入了11项RCT，共895例患者。结果表明，DHJSD能显著提高有效率（OR = 3.13，95%CI = 2.07 ~ 4.72，P < 0.001），降低WOMAC（MD = −12.06，95%CI = -16.34至-7.79，P < 0.001）和VAS（MD =-1.02，95%CI = -1.54 ~-0.50，P = 0.0001）评分，并降低血清IL-6寒湿痹阻型KOA治疗前后血清TNF-α（MD =-0.80，95%CI = -0.90 ~-0.69，P < 0.001）和TNF-α（MD =-2.49，95%CI = -2.77 ~-2.21，P < 0.001）水平的变化。亚组分析显示，与硫酸氨基葡萄糖（GS）单用相比，DHJSD联合GS显著提高了有效率（OR = 2.59，95%CI = 1.19 ~ 5.65，P = 0.02）并降低WOMAC（MD = −13.83，95%CI = -16.14至-11.51，P < 0.001）和VAS（MD = −0.91，95%CI = -1.27至-0.55，P < 0.001）评分。DHJSD +温针灸（WA）降低VAS评分比单独WA更明显。DHJSD组血清IL-1β水平与对照组相比无显著性差异。 本研究表明，加味东菱克栓汤治疗寒湿痹阻型膝关节骨性关节炎可提高临床疗效，降低VAS和WOMAC评分。与单用GS或WA相比，DHJSD与GS或WA联合应用可更好地降低VAS和WOMAC评分。
The aim of this study is to provide evidence of the effect of Duhuo Jisheng decoction (DHJSD) on knee osteoarthritis (KOA) of the cold-dampness obstruction syndrome type. We searched PubMed, Embase, the Cochrane Library, the China National Knowledge Infrastructure, the Wanfang database, and the China Biology Medicine for randomized controlled trials (RCTs) evaluating DHJSD or DHJSD combined with other conventional therapies (DHJSD group) compared to conventional therapy (control group) for cold-dampness obstruction syndrome-type KOA. We calculated the pooled odds ratio (OR), mean difference (MD), and 95% confidence interval (CI) using fixed- or random-effects models. Eleven RCTs, with a total of 895 patients, were included. The results showed that DHJSD could significantly improve the effective rate (OR = 3.13, 95%CI = 2.07 to 4.72, P < 0.001), reduce both the WOMAC (MD = −12.06, 95%CI = -16.34 to -7.79, P < 0.001) and VAS (MD = −1.02, 95%CI = -1.54 to -0.50, P = 0.0001) scores, and reduce the serum IL-6 (MD = −0.80, 95%CI = -0.90 to -0.69, P < 0.001) and TNF-α (MD = −2.49, 95%CI = -2.77 to -2.21, P < 0.001) levels during the treatment of cold-dampness obstruction syndrome-type KOA. The subgroup analysis showed that compared with glucosamine sulfate (GS) alone, DHJSD combined with GS significantly improved the effective rate (OR = 2.59, 95%CI = 1.19 to 5.65, P = 0.02) and reduced the WOMAC (MD = −13.83, 95%CI = -16.14 to -11.51, P < 0.001) and VAS (MD = −0.91, 95%CI = -1.27 to -0.55, P < 0.001) scores. DHJSD + warm-needle acupuncture (WA) lowered the VAS score more than WA alone. There was no significant difference in the decrease in serum IL-1β between the DHJSD and control groups. This study shows that DHJSD can improve the clinical efficacy and reduce the VAS and WOMAC scores in the treatment of cold-dampness obstruction syndrome-type KOA. Compared with GS or WA alone, the combined application of DHJSD with GS or WA could better reduce both the VAS and WOMAC scores.
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影响因子：
5.1
作者：
Vina ER;Kwoh CK
通讯作者：
Kwoh CK
DOI：
10.5435/jaaos-22-04-256
发表时间：
2014-04-01
影响因子：
3.2
作者：
Sanders, James O.;Murray, Jayson;Gross, Leeaht
通讯作者：
Gross, Leeaht
影响因子：
3.4
作者：
Dantas, Lucas Ogura;Salvini, Tania de Fatima;McAlindon, Timothy E.
通讯作者：
McAlindon, Timothy E.
DOI：
10.1155/2020/7275057
发表时间：
2020
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Xiao W;Sun W;Lian H;Shen J
通讯作者：
Shen J
影响因子：
5.6
作者：
Liu L;Xu L;Wang S;Wang L;Wang X;Xu H;Li X;Ye H
通讯作者：
Ye H