Regulatory T Cells in Chronic Heart Failure.
Regulatory T Cells in Chronic Heart Failure.
复制标题
慢性心力衰竭中的调节性 T 细胞
DOI：
10.3389/fimmu.2021.732794
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发表时间：
2021
影响因子：
7.3
通讯作者：
Cheng X
中科院分区：
文献类型：
--
作者：
Lu Y;Xia N;Cheng X
心力衰竭是一个全球性问题，住院率和死亡率很高。炎症和免疫功能障碍参与了这种疾病。由于其独特的功能，调节性T细胞（Tcells，Tcells）最近重新引起人们的关注。它们参与心力衰竭病理生理学中的免疫调节和组织修复。在心脏损伤的早期阶段，睾酮通过抑制过度的炎症反应和促进稳定的瘢痕形成而对心脏有益。然而，在慢性心力衰竭中，TdR的表型和功能发生了变化。它们转化为抗血管生成和促纤维化的细胞类型。本文首先对TGFAP在慢性心力衰竭发生发展中的作用进行综述。然后，我们专注于TdR与其靶细胞之间的相互作用。T细胞的靶细胞包括免疫细胞（如单核细胞/巨噬细胞、树突细胞、T细胞和B细胞）和实质细胞（如心肌细胞、成纤维细胞和内皮细胞）。下一代测序和基因编辑技术使心力衰竭的免疫治疗成为可能。因此，也对基于TdR的慢性心力衰竭的前瞻性治疗方法进行了评价。
Heart failure is a global problem with high hospitalization and mortality rates. Inflammation and immune dysfunction are involved in this disease. Owing to their unique function, regulatory T cells (Tregs) have reacquired attention recently. They participate in immunoregulation and tissue repair in the pathophysiology of heart failure. Tregs are beneficial in heart by suppressing excessive inflammatory responses and promoting stable scar formation in the early stage of heart injury. However, in chronic heart failure, the phenotypes and functions of Tregs changed. They transformed into an antiangiogenic and profibrotic cell type. In this review, we summarized the functions of Tregs in the development of chronic heart failure first. Then, we focused on the interactions between Tregs and their target cells. The target cells of Tregs include immune cells (such as monocytes/macrophages, dendritic cells, T cells, and B cells) and parenchymal cells (such as cardiomyocytes, fibroblasts, and endothelial cells). Next-generation sequencing and gene editing technology make immunotherapy of heart failure possible. So, prospective therapeutic approaches based on Tregs in chronic heart failure had also been evaluated.
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影响因子：
20.3
作者：
Borsellino, Giovanna;Kleinewietfeld, Markus;Falk, Kirsten
通讯作者：
Falk, Kirsten
急性冠脉综合征患者Th17/Treg失衡
影响因子：
8.6
作者：
Cheng, Xiang;Yu, Xian;Liao, Yu-hua
通讯作者：
Liao, Yu-hua
DOI：
10.1007/s12265-018-9794-0
发表时间：
2018-06-01
影响因子：
3.4
作者：
Chen, Zhisong;Yan, Wenwen;Shen, Yuqin
通讯作者：
Shen, Yuqin
DOI：
10.5114/ceji.2016.58817
发表时间：
2016
期刊：
Central-European journal of immunology
影响因子：
--
作者：
Cheng H;Xi Y;Chi X;Wu Y;Liu G
通讯作者：
Liu G
影响因子：
4.4
作者：
Gondek, DC;Lu, LF;Noelle, RJ
通讯作者：
Noelle, RJ