Serotonin modulates the effects of Pavlovian aversive predictions on response vigor.
Serotonin modulates the effects of Pavlovian aversive predictions on response vigor.
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DOI：
10.1038/npp.2012.75
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发表时间：
2012-09
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影响因子：
--
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中科院分区：
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关于5-羟色胺(5-羟色胺)在动机中的作用的最新理论研究表明，5-羟色胺在厌恶和抑制的交叉点上运作，在面对厌恶的预测时促进戒断。然而，5-羟色胺调节戒断行为的具体认知机制仍然知之甚少。对惩罚反应的行为抑制反映了至少两个同时进行的过程：工具性厌恶预测将刺激、反应和惩罚联系起来，巴甫洛夫厌恶预测将刺激和惩罚联系起来，而不管反应如何。在目前的研究中，我们考察了5-羟色胺在多大程度上调节工具性预测与巴甫洛夫厌恶预测对行为抑制的影响。我们使用急性色氨酸耗竭来降低健康志愿者的中枢5-羟色胺水平，并在一项新的任务中观察了行为，该任务旨在衡量巴甫洛夫和工具性厌恶预测对选择(反应偏差)和反应活力(反应潜伏期)的影响。在安慰剂治疗后，参与者对导致惩罚的按钮反应有偏见，而且他们在惩罚背景下的反应比非惩罚背景下的反应慢。具体地说，参与者在出现预示惩罚的刺激时放慢了他们的反应。色氨酸耗竭消除了对惩罚按钮上反应的偏见，并取消了在存在惩罚刺激时减速，而不管反应如何。我们认为，这组结果可以通过5-羟色胺在巴甫洛夫厌恶预测中的作用来解释。这些发现表明，5-羟色胺对厌恶动机行为抑制的影响具有额外的特异性，并扩展了最近关于5-羟色胺在厌恶预测中的作用的模型。
Updated theoretical accounts of the role of serotonin (5-HT) in motivation propose that 5-HT operates at the intersection of aversion and inhibition, promoting withdrawal in the face of aversive predictions. However, the specific cognitive mechanisms through which 5-HT modulates withdrawal behavior remain poorly understood. Behavioral inhibition in response to punishments reflects at least two concurrent processes: instrumental aversive predictions linking stimuli, responses, and punishments, and Pavlovian aversive predictions linking stimuli and punishments irrespective of response. In the current study, we examined to what extent 5-HT modulates the impact of instrumental vs Pavlovian aversive predictions on behavioral inhibition. We used acute tryptophan depletion to lower central 5-HT levels in healthy volunteers, and observed behavior in a novel task designed to measure the influence of Pavlovian and instrumental aversive predictions on choice (response bias) and response vigor (response latencies). After placebo treatment, participants were biased against responding on the button that led to punishment, and they were slower to respond in a punished context, relative to a non-punished context. Specifically, participants slowed their responses in the presence of stimuli predictive of punishments. Tryptophan depletion removed the bias against responding on the punished button, and abolished slowing in the presence of punished stimuli, irrespective of response. We suggest that this set of results can be explained by a role for 5-HT in Pavlovian aversive predictions. These findings suggest additional specificity for the influence of 5-HT on aversively motivated behavioral inhibition and extend recent models of the role of 5-HT in aversive predictions.
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DOI：
10.1016/b978-0-12-374176-9.00012-9
发表时间：
2009-01-01
期刊：
NEUROECONOMICS: DECISION MAKING AND THE BRAIN
影响因子：
--
作者：
Dayan, Peter;Seymour, Ben
通讯作者：
Seymour, Ben
影响因子：
4.3
作者：
Huys QJ;Cools R;Gölzer M;Friedel E;Heinz A;Dolan RJ;Dayan P
通讯作者：
Dayan P
影响因子：
7.6
作者：
Avila, C
通讯作者：
Avila, C
DOI：
10.1523/jneurosci.2513-09.2009
发表时间：
2009-09-23
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Crockett MJ;Clark L;Robbins TW
通讯作者：
Robbins TW
影响因子：
1.4
作者：
BOLLES, RC;HOLTZ, R;HILL, W
通讯作者：
HILL, W