AMPed-up adolescents: The role of age in the abuse of amphetamines and its consequences on cognition and prefrontal cortex development.
AMPed-up adolescents: The role of age in the abuse of amphetamines and its consequences on cognition and prefrontal cortex development.
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DOI：
10.1016/j.pbb.2020.173016
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发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Gulley JM
中科院分区：
文献类型：
--
作者：
Westbrook SR;Carrica LK;Banks A;Gulley JM
青少年使用安非他明及其密切相关的甲基化版本甲基苯丙胺，在那些将药物用于非医疗目的的人中，比例高得惊人。这引发了人们对这种药物使用可能对青春期大脑正常发育和行为产生长期有害影响的严重担忧。在这篇综述中，我们探索了人类和实验动物研究的最新发现，这些研究调查了在生命的这一阶段接触苯丙胺和甲基苯丙胺的后果。我们重点介绍了评估青春期性别差异的研究，以及那些专门为解决青少年暴露的潜在独特影响而设计的研究，这些研究包括处于其他生命阶段(通常是青年时期)的群体。我们认为，年龄和性别的流行病学研究是安非他明使用中出现问题的易感因素，人类和动物的实验室研究也是如此，这些研究探讨了使用安非他明的年龄差异、其对行为的短期影响以及这种暴露对认知的长期影响。我们还专注于对前额叶皮质药物效应的研究，众所周知，前额叶皮质对认知至关重要，是较晚成熟的大脑区域之一。最后，我们讨论了在未来的研究中应该解决的重要问题，以便该领域能够进一步了解青少年使用苯丙胺的潜在机制及其对发育中的大脑和行为的影响。
Adolescent use of amphetamine and its closely related, methylated version methamphetamine, is alarmingly high in those who use drugs for nonmedical purposes. This raises serious concerns about the potential for this drug use to have a long-lasting, detrimental impact on the normal development of the brain and behavior that is ongoing during adolescence. In this review, we explore recent findings from both human and laboratory animal studies that investigate the consequences of amphetamine and methamphetamine exposure during this stage of life. We highlight studies that assess sex differences in adolescence, as well as those that are designed specifically to address the potential unique effects of adolescent exposure by including groups at other life stages (typically young adulthood). We consider epidemiological studies on age and sex as vulnerability factors for developing problems with the use of amphetamines, as well as human and animal laboratory studies that tap into age differences in use, its short-term effects on behavior, and the long-lasting consequences of this exposure on cognition. We also focus on studies of drug effects in the prefrontal cortex, which is known to be critically important for cognition and is among the later maturing brain regions. Finally, we discuss important issues that should be addressed in future studies so that the field can further our understanding of the mechanisms underlying adolescent use of amphetamines and its outcomes on the developing brain and behavior.
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影响因子：
1.6
作者：
Brown, Russell W.;Perna, Marla K.;Smith, Meredith L.
通讯作者：
Smith, Meredith L.
影响因子：
2.9
作者：
Cuzen NL;Koopowitz SM;Ferrett HL;Stein DJ;Yurgelun-Todd D
通讯作者：
Yurgelun-Todd D
影响因子：
11
作者：
Berman, S. M.;Kuczenski, R.;McCracken, J. T.;London, E. D.
通讯作者：
London, E. D.
DOI：
10.1016/s0165-3806(98)00116-3
发表时间：
1998-11-01
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
Bolanos, CA;Glatt, SJ;Jackson, D
通讯作者：
Jackson, D
影响因子：
3.6
作者：
Cadet, Jean Lud;Patel, Ravish;Jayanthi, Subramaniam
通讯作者：
Jayanthi, Subramaniam