Low prevalence of varicella zoster virus and herpes simplex virus type 2 in saliva from human immunodeficiency virus-infected persons in the era of highly active antiretroviral therapy.
Low prevalence of varicella zoster virus and herpes simplex virus type 2 in saliva from human immunodeficiency virus-infected persons in the era of highly active antiretroviral therapy.
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在高度活跃的抗逆转录病毒疗法时代，人类免疫缺陷病毒感染者的唾液中的水痘带状疱疹病毒和单纯疱疹病毒的患病率低。
DOI：
10.1016/j.tripleo.2009.08.037
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发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
Miller, Craig S.
中科院分区：
文献类型：
--
作者：
Wang, Chunmei C.;Yepes, Luis C.;Danaher, Robert J.;Berger, Joseph R.;Mootoor, Yunanan;Kryscio, Richard J.;Miller, Craig S.
人疱疹病毒（HHV），例如单纯疱疹病毒（HSV）1型、爱泼斯坦-巴尔病毒和巨细胞病毒，在感染人免疫缺陷病毒（HIV）的人中比健康个体更频繁地出现在唾液中。然而，目前尚不清楚水痘带状疱疹病毒（VZV）和HSV-2是否同时出现在艾滋病毒感染期间，在唾液中的频率更高，在这个时代的高活性抗逆转录病毒治疗（HAART）。本研究的目的是调查VZV和HSV-2在艾滋病毒感染的口腔无症状患者唾液中的流行率和数量。定量聚合酶链反应被用来调查的患病率，数量，风险和唾液VZV和HSV-2的相关性，从59个HIV血清阳性的个人和53名健康对照的病例对照，横断面研究。78%（46/59）的HIV血清阳性患者正在接受HAART治疗。在HIV阳性组的5.1%（3/59）的唾液中检测到VZV DNA，仅在一名健康对照组中检测到1.9%（1/53; P = 0.62）。表达者中VZV DNA的量较低，通常低于1，100拷贝/mL，在HIV阳性组和对照组之间没有观察到差异（P= 1.0）。两组均未检出HSV-2 DNA。在HIV感染组中，VZV脱落发生在HAART治疗组中，但与口腔病变、特异性CD 4+或CD 8 + T细胞水平或人口统计学因素无关。在HIV感染者的唾液中检测到VZV的低流行率，而在该队列的唾液中未检测到HSV-2。HAART似乎并没有降低无症状VZV脱落的风险。
Human herpesviruses (HHVs), e.g. herpes simplex virus (HSV) type 1, Epstein-Barr virus and cytomegalovirus, appear in saliva at greater frequency in persons infected with human immunodeficiency virus (HIV) than healthy individuals. However, it is not known if varicella zoster virus (VZV) and HSV-2 appear simultaneously during HIV infection at greater frequency in saliva during this era of highly active antiretroviral therapy (HAART). The aim of this study was to investigate the prevalence and amounts of VZV and HSV-2 in the saliva of HIV-infected, orally asymptomatic patients. Quantitative polymerase chain reaction was used to investigate the prevalence, quantity, risk, and correlates of salivary VZV and HSV-2 from 59 HIV-seropositive individuals and 53 healthy controls in a case-control, cross-sectional study. Seventy-eight percent of the HIV-seropositive patients (46/59) were taking HAART. VZV DNA was detected in the saliva of 5.1% (3/59) of the HIV-positive group and in only one healthy control 1.9% (1/53; P = 0.62). The amount of VZV DNA in the expressors was low, generally less than 1,100 copies/mL with no observed difference between the HIV-positive group and the controls (P= 1.0). HSV-2 DNA was not detected in either group. In the HIV-infected group, VZV shedding occurred in those on HAART, but was not associated with oral lesions, specific CD4+ or CD8+ T-cell levels, or demographic factors. VZV was detected at low prevalence in the saliva of HIV-infected persons whereas HSV-2 was not detected in the saliva of this cohort. HAART does not appear to diminish the risk for asymptomatic VZV shedding.
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影响因子：
3.7
作者：
Abu-Raddad LJ;Magaret AS;Celum C;Wald A;Longini IM Jr;Self SG;Corey L
通讯作者：
Corey L
影响因子：
5.4
作者：
Cohrs, RJ;Randall, J;Tal-Singer, R
通讯作者：
Tal-Singer, R
影响因子：
12.7
作者：
DOCHERTY, JJ;TRIMBLE, J;ZIMMERMAN, DH
通讯作者：
ZIMMERMAN, DH
影响因子：
9.4
作者：
Druce, J;Catton, M;Birch, C
通讯作者：
Birch, C
影响因子：
1.4
作者：
Dunic, I;Djurkovic-Djakovic, O;Jevtovic, D
通讯作者：
Jevtovic, D