Interaction of the Macrophage and Primitive Erythroid Lineages in the Mammalian Embryo.
Interaction of the Macrophage and Primitive Erythroid Lineages in the Mammalian Embryo.
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DOI：
10.3389/fimmu.2016.00669
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发表时间：
2016
影响因子：
7.3
通讯作者：
Palis J
中科院分区：
文献类型：
--
作者：
Palis J
在哺乳动物中发现了两种不同形式的红细胞生成，原始的和永久的。骨髓中的促红细胞前体在“成红细胞岛”中的巨噬细胞的物理环境中成熟。在小鼠胚胎中，在造血干细胞出现之前，卵黄囊中出现原始造血祖细胞和定形红骨髓祖细胞的重叠波，每一波都含有巨噬细胞潜能。原始成红细胞在血流中作为半同步队列成熟，而来自卵黄囊的巨噬细胞在胎肝中播种。晚期原始成红细胞与巨噬细胞在胎肝中的成红细胞岛中相关联，表明原始成红细胞可以与巨噬细胞在血管外相互作用。与定形成红细胞一样，原始成红细胞通过α4整联蛋白-血管粘附分子1介导的相互作用与巨噬细胞物理结合，α4整联蛋白重新分布到原始蛋白核细胞的质膜上。在体外和体内研究表明，胎肝巨噬细胞吞噬原始蛋白核细胞。总之，这些研究表明，在哺乳动物生物体的个体发育过程中，巨噬细胞和成熟的红系前体细胞之间的相互作用的几个方面是保守的。
Two distinct forms of erythropoiesis, primitive and definitive, are found in mammals. Definitive erythroid precursors in the bone marrow mature in the physical context of macrophage cells in “erythroblastic islands.” In the murine embryo, overlapping waves of primitive hematopoietic progenitors and definitive erythro-myeloid progenitors, each containing macrophage potential, arise in the yolk sac prior to the emergence of hematopoietic stem cells. Primitive erythroblasts mature in the bloodstream as a semi-synchronous cohort while macrophage cells derived from the yolk sac seed the fetal liver. Late-stage primitive erythroblasts associate with macrophage cells in erythroblastic islands in the fetal liver, indicating that primitive erythroblasts can interact with macrophage cells extravascularly. Like definitive erythroblasts, primitive erythroblasts physically associate with macrophages through α4 integrin–vascular adhesion molecule 1-mediated interactions and α4 integrin is redistributed onto the plasma membrane of primitive pyrenocytes. Both in vitro and in vivo studies indicate that fetal liver macrophage cells engulf primitive pyrenocytes. Taken together, these studies indicate that several aspects of the interplay between macrophage cells and maturing erythroid precursor cells are conserved during the ontogeny of mammalian organisms.
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影响因子：
56.9
作者：
Kawane, K;Fukuyama, H;Nagata, S
通讯作者：
Nagata, S
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
2.6
作者：
Ferkowicz, MJ;Yoder, MC
通讯作者：
Yoder, MC
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
64.5
作者：
Gosselin D;Link VM;Romanoski CE;Fonseca GJ;Eichenfield DZ;Spann NJ;Stender JD;Chun HB;Garner H;Geissmann F;Glass CK
通讯作者：
Glass CK