H. pylori virulence factors: influence on immune system and pathology.
H. pylori virulence factors: influence on immune system and pathology.
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DOI：
10.1155/2014/426309
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发表时间：
2014
影响因子：
4.6
通讯作者：
Gerhard M
中科院分区：
文献类型：
--
作者：
Kalali B;Mejías-Luque R;Javaheri A;Gerhard M
幽门螺杆菌是人类中分布最广的慢性细菌病原体，并因其与溃疡疾病和胃癌的关系而得到广泛认可，这两种疾病都代表着重大的全球健康和社会经济问题。鉴于这种细菌与人类宿主的高度适应和共同进化，为了开发新的预防治疗手段，需要对这种感染的特定微生物特征以及宿主生理学进行全面和多方位的观察。这篇综述旨在指出这些潜在的重要角度，这些角度在研究幽门螺旋杆菌的致病性时必须相互考虑。宿主因毒力因素引起的生物学变化是幽门螺杆菌研究的重要支柱，细菌引起这些变化的机制也是研究的重要支柱。在此背景下，讨论了幽门螺杆菌必需的粘附分子和重要的毒力因子。此外，代谢的细菌，最重要的方面之一，为更好地了解细菌生理和可能的治疗和预防策略，是解决。另一方面，我们讨论了最近与幽门螺杆菌感染相关的“卫生假说”的实验证据，这为这种感染增加了另一个方面的复杂性。
Helicobacter pylori is the most widespread chronic bacterial agent in humans and is well recognized for its association with ulcer disease and gastric cancer, with both representing major global health and socioeconomic issues. Given the high level of adaptation and the coevolution of this bacterium with its human host, a thorough and multidirectional view of the specific microbiological characteristics of this infection as well as the host physiology is needed in order to develop novel means of prevention of therapy. This review aims to pinpoint some of these potentially important angles, which have to be considered mutually when studying H. pylori's pathogenicity. The host's biological changes due to the virulence factors are a valuable pillar of H. pylori research as are the mechanisms by which bacteria provoke these changes. In this context, necessary adhesion molecules and significant virulence factors of H. pylori are discussed. Moreover, metabolism of the bacteria, one of the most important aspects for a better understanding of bacterial physiology and consequently possible therapeutic and prophylactic strategies, is addressed. On the other hand, we discuss the recent experimental proofs of the “hygiene hypothesis” in correlation with Helicobacter's infection, which adds another aspect of complexity to this infection.
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DOI：
10.1086/590158
发表时间：
2008-08-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Chen Y;Blaser MJ
通讯作者：
Blaser MJ
影响因子：
3
作者：
FERRERO, RL;HAZELL, SL;LEE, A
通讯作者：
LEE, A
DOI：
10.1073/pnas.93.25.14648
发表时间：
1996-12-10
影响因子：
11.1
作者：
Censini, S;Lange, C;Covacci, A
通讯作者：
Covacci, A
影响因子：
3.2
作者：
Benoit, S;Maier, RJ
通讯作者：
Maier, RJ
影响因子：
11.2
作者：
Franco, Aime T.;Johnston, Elizabeth;Peek, Richard M., Jr.
通讯作者：
Peek, Richard M., Jr.