A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with the risk of squamous cell carcinoma of the head and neck.
A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with the risk of squamous cell carcinoma of the head and neck.
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DOI：
10.1002/cncr.25058
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发表时间：
2010-06-15
期刊：
影响因子：
6.2
通讯作者：
Wei, Qingyi
中科院分区：
文献类型：
--
作者：
Wei, Sheng;Liu, Zhensheng;Zhao, Hui;Niu, Jiangong;Wang, Li-E;El-Naggar, Adel K.;Sturgis, Erich M.;Wei, Qingyi
我们对1110例SCCHN病例和1129例对照进行了一项基于医院的研究，以复制最近欧洲一项大型研究报告的酒精脱氢酶基因ADH 1B R48 H的两个潜在功能性单核苷酸多态性（SNP）之间的关联。（rs 1229984：G>A）和ADH 7 A92 G（rs 1573496：C>G）与头颈部鳞状细胞癌（SCCHN）的风险相关。采用多变量logistic回归分析计算调整后的比值比（OR）和95%置信区间（95%CI）。还计算了重大发现的假阳性报告概率。我们发现，与CC基因型相比，ADH 7A 92 G GG和CG+GG组合基因型与SCCHN风险降低相关（调整后OR，0.32; GG的95%CI，0.13-0.82，调整后OR，0.74; CG+GG的95%CI，0.59-0.94; FPRP，0.098）。这种关联在老年（> 57岁）受试者、男性、既往吸烟者、口腔癌和N 0淋巴结转移的亚组中也很明显（所有亚组P <0.05）;然而，在ADH 1B R48 H SNP中没有观察到这种关联。我们的研究结果支持ADH 7 A92 G SNP作为非西班牙裔白色人群中SCCHN风险的标志物。
We conducted a hospital-based study of 1110 SCCHN cases and 1129 controls to replicate the associations reported by a recent large European study between two potentially functional single nucleotide plymorphisms (SNPs) of the alcohol dehydrogenases genes, ADH1B R48H (rs1229984: G>A) and ADH7 A92G (rs1573496: C>G), and risk of squamous cell carcinoma of the head and neck (SCCHN). Multivariate logistic regression was used to calculate adjusted odds ratios (OR) and 95% confidence intervals (95% CI). False-positive report probabilities were also calculated for significant findings. We found that the ADH7A92G GG and combined CG+GG genotypes were associated with a decreased risk of SCCHN (adjusted OR, 0.32; 95% CI, 0.13-0.82 for GG and adjusted OR, 0.74; 95% CI, 0.59-0.94 for CG+GG; FPRP, .098) compared with the CC genotype. This association was also evident in subgroups of older (> 57 years) subjects, males, former smokers, oral cancer, and N0 lymph node metastasis (P < .05 for all); however, such associations were not observed for the ADH1B R48H SNP. Our results support the ADH7 A92G SNP as a marker for risk of SCCHN in non-Hispanic White populations.
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影响因子：
9.8
作者：
Osier, MV;Pakstis, AJ;Kidd, KK
通讯作者：
Kidd, KK
DOI：
10.1093/jnci/djk179
发表时间：
2007-05-16
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Hashibe, Mia;Brennan, Paul;Boffetta, Paolo
通讯作者：
Boffetta, Paolo
影响因子：
30.8
作者：
Hashibe, Mia;Mckay, James D.;Brennan, Paul
通讯作者：
Brennan, Paul
影响因子：
254.7
作者：
Parkin, DM;Bray, F;Pisani, P
通讯作者：
Pisani, P
影响因子：
3.5
作者：
Birley, Andrew J.;James, Michael R.;Whitfield, John B.
通讯作者：
Whitfield, John B.