Inactivation of Human Coronavirus by Titania Nanoparticle Coatings and UVC Radiation: Throwing Light on SARS-CoV-2.
Inactivation of Human Coronavirus by Titania Nanoparticle Coatings and UVC Radiation: Throwing Light on SARS-CoV-2.
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DOI：
10.3390/v13010019
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发表时间：
2020-12-24
期刊：
影响因子：
--
通讯作者：
Verma SC
中科院分区：
文献类型：
--
作者：
Khaiboullina S;Uppal T;Dhabarde N;Subramanian VR;Verma SC
新发现的致病性人类冠状病毒SARS-CoV-2导致了一场非典型肺炎样严重急性呼吸综合征（SARS）疫情，称为冠状病毒病2019（简称COVID-19）。目前，全球已确诊近7700万例，其中美国的COVID-19病例数最高。个人正在接种最近批准的疫苗，这些疫苗在抑制COVID-19症状方面具有高度保护性，但在大多数人接种疫苗之前还有很长的路要走。与此同时，安全预防措施和有效的疾病控制策略似乎对防止病毒在公共场所传播至关重要。由于病毒在光滑表面上的寿命，“自消毒/清洁”表面的光催化性能似乎是一种有前途的工具，可以帮助指导控制SARS-CoV-2在医院，杂货店，机场，学校和体育场等高流量区域传播的消毒政策。在这里，我们探讨了纳米二氧化钛（TNP）的光催化性能的紫外线辐射诱导，对病毒灭活。我们使用SAR-CoV-2的近亲HCoV-NL 63的初步结果显示了沉积在盖玻片上的光敏TNP的杀病毒功效，如通过定量RT-qPCR和病毒感染性测定所检查的。目前正在努力将本研究中描述的基本概念外推到SARS-CoV-2。
The newly identified pathogenic human coronavirus, SARS-CoV-2, led to an atypical pneumonia-like severe acute respiratory syndrome (SARS) outbreak called coronavirus disease 2019 (abbreviated as COVID-19). Currently, nearly 77 million cases have been confirmed worldwide with the highest numbers of COVID-19 cases in the United States. Individuals are getting vaccinated with recently approved vaccines, which are highly protective in suppressing COVID-19 symptoms but there will be a long way before the majority of individuals get vaccinated. In the meantime, safety precautions and effective disease control strategies appear to be vital for preventing the virus spread in public places. Due to the longevity of the virus on smooth surfaces, photocatalytic properties of “self-disinfecting/cleaning” surfaces appear to be a promising tool to help guide disinfection policies for controlling SARS-CoV-2 spread in high-traffic areas such as hospitals, grocery stores, airports, schools, and stadiums. Here, we explored the photocatalytic properties of nanosized TiO2 (TNPs) as induced by the UV radiation, towards virus deactivation. Our preliminary results using a close genetic relative of SAR-CoV-2, HCoV-NL63, showed the virucidal efficacy of photoactive TNPs deposited on glass coverslips, as examined by quantitative RT-qPCR and virus infectivity assays. Efforts to extrapolate the underlying concepts described in this study to SARS-CoV-2 are currently underway.
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