Advances in Intestinal Barrier Preservation and Restoration in the Allogeneic Hematopoietic Cell Transplantation Setting.
Advances in Intestinal Barrier Preservation and Restoration in the Allogeneic Hematopoietic Cell Transplantation Setting.
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DOI：
10.3390/jcm10112508
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发表时间：
2021-06-06
影响因子：
3.9
通讯作者：
Basak GW
中科院分区：
文献类型：
--
作者：
Tyszka M;Biliński J;Basak GW
肠道屏障由覆盖有肠道微生物群所居住的专门粘液的上皮衬里组成。完整的肠道屏障确保了对细菌和毒素移位的抵抗力。另一方面，肠道渗透性允许吸收必需的营养素、液体和离子。这种平衡只有通过肠道屏障的复杂结构和功能特性才能实现。同种异体造血细胞移植仍然是许多血液病的唯一治愈性治疗方法，但其应用受到限制，因为主要由于移植物抗宿主病和感染并发症可能导致移植相关死亡。近年来，肠道屏障作为移植物抗宿主病发生和传播的主要部位已被广泛研究。在本综述中，我们重点介绍了肠道屏障的生理结构和功能，以及肠道屏障破坏和肠道通透性增加如何影响移植受者的证据。最后，针对肠道屏障保护的治疗策略进行了讨论，特别关注异基因造血细胞移植环境中微生物组的保存和恢复。
The intestinal barrier consists of an epithelial lining covered with specialized mucus inhabited by intestinal microbiota. An intact gut barrier ensures a resistance to bacteria and toxins translocation. On the other hand, gut permeability allows the absorption of essential nutrients, fluids and ions. This balance is achieved only by the complex structure and functional characteristics of the intestinal barrier. Allogenic hematopoietic cell transplantation remains the only curative treatment for many hematological diseases, but its application is limited because of possible transplant-related mortality mainly due to graft-versus-host disease and infectious complications. The intestinal barrier has been extensively studied in recent years as the primary site of graft-versus-host disease initiation and propagation. In the present review, we focused on the physiological structure and function of the gut barrier and the evidence of how the disruption of the gut barrier and increased intestinal permeability affects transplant recipients. Finally, therapeutic strategies aiming at intestinal barrier protection with a special focus on microbiome preservation and restoration in the allogenic hematopoietic cell transplantation setting are discussed.
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影响因子：
64.8
作者：
Brandl, Katharina;Plitas, George;Mihu, Coralia N.;Ubeda, Carles;Jia, Ting;Fleisher, Martin;Schnabl, Bernd;DeMatteo, Ronald P.;Pamer, Eric G.
通讯作者：
Pamer, Eric G.
DOI：
10.1016/j.bbmt.2014.01.030
发表时间：
2014-05
期刊：
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
影响因子：
--
作者：
Holler E;Butzhammer P;Schmid K;Hundsrucker C;Koestler J;Peter K;Zhu W;Sporrer D;Hehlgans T;Kreutz M;Holler B;Wolff D;Edinger M;Andreesen R;Levine JE;Ferrara JL;Gessner A;Spang R;Oefner PJ
通讯作者：
Oefner PJ
影响因子：
2.4
作者：
Bischoff SC;Barbara G;Buurman W;Ockhuizen T;Schulzke JD;Serino M;Tilg H;Watson A;Wells JM
通讯作者：
Wells JM
影响因子：
4.8
作者：
Johansson, JE;Ekman, T
通讯作者：
Ekman, T
影响因子：
4.2
作者：
Galloway-Pena, Jessica R.;Peterson, Christine B.;Okhuysen, Pablo C.
通讯作者：
Okhuysen, Pablo C.