Persistent Immune Activation in Human Immunodeficiency Virus-Infected Pregnant Women Starting Combination Antiretroviral Therapy After Conception.
Persistent Immune Activation in Human Immunodeficiency Virus-Infected Pregnant Women Starting Combination Antiretroviral Therapy After Conception.
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DOI：
10.1093/infdis/jiab095
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发表时间：
2022-04-01
期刊：
影响因子：
--
通讯作者：
Thea DM
中科院分区：
文献类型：
--
作者：
Lohman-Payne B;Koster J;Gabriel B;Chilengi R;Forman LS;Heeren T;Duffy CR;Herlihy J;Crimaldi S;Gill C;Chavuma R;Mwananyanda L;Thea DM
本研究评估了赞比亚一组HIV暴露但未感染儿童从出生起随访的妊娠期人类免疫缺陷病毒（HIV）和联合抗逆转录病毒治疗（cART）对免疫激活的影响。在未感染HIV的孕妇（n = 95）、经历过cART的HIV感染孕妇（n = 111）和未接受过cART的HIV感染孕妇（n = 21）中比较活化的CD 8 + T细胞（CD 38+和HLA-DR+）。 HIV感染/cART初治妇女的免疫激活最高，但在妊娠期间下降。在妊娠期间开始cART的HIV感染女性的免疫激活水平降低，但未达到与HIV未感染女性相似的水平。妊娠期母体免疫激活水平升高对随后婴儿健康和免疫力的影响仍有待确定。在妊娠期间开始联合抗逆转录病毒治疗（cART）的人类免疫缺陷病毒（HIV）感染女性的T细胞免疫活化水平降低，但未达到与妊娠cART经历的HIV感染或HIV未感染女性相似的水平。母亲在生命早期的免疫激活对婴儿免疫力的影响仍不明确。
This study evaluated the impact of human immunodeficiency virus (HIV) and combination antiretroviral therapy (cART) on immune activation during pregnancy in a Zambian cohort of HIV-exposed but uninfected children followed up from birth. Activated CD8+ T cells (CD38+ and HLA-DR+) were compared among HIV-uninfected (n = 95), cART experienced HIV-infected (n = 111), and cART-naive HIV-infected (n = 21) pregnant women. Immune activation was highest among HIV-infected/cART-naive women but decreased during pregnancy. Immune activation HIV-infected women who started cART during pregnancy was reduced but not to levels similar to those in HIV-uninfected women. The effects of elevated maternal immune activation in pregnancy on subsequent infant health and immunity remain to be determined. Human immunodeficiency virus (HIV)–infected women who started combination antiretroviral therapy (cART) during pregnancy experienced reduced T-cell immune activation but not to levels similar to those in pregnant cART-experienced HIV-infected or HIV-uninfected women. The effect of maternal immune activation during early life on infant immunity remains undefined.
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影响因子：
3.4
作者：
Mikyas, Y;Aziz, N;Plaeger, S
通讯作者：
Plaeger, S
影响因子：
3.8
作者：
Brennan, Alana T.;Bonawitz, Rachael;Fox, Matthew P.
通讯作者：
Fox, Matthew P.
影响因子：
3.8
作者：
Bunders, M;Thorne, C;Iorio, R
通讯作者：
Iorio, R
影响因子：
3.4
作者：
Tuaillon, Edouard;Al Tabaa, Yassine;Vendrell, Jean-Pierre
通讯作者：
Vendrell, Jean-Pierre
DOI：
10.1111/aji.12289
发表时间：
2014-08
期刊：
American journal of reproductive immunology (New York, N.Y. : 1989)
影响因子：
--
作者：
Racicot K;Kwon JY;Aldo P;Silasi M;Mor G
通讯作者：
Mor G