fMRI response in the medial prefrontal cortex predicts cocaine but not sucrose self-administration history.
fMRI response in the medial prefrontal cortex predicts cocaine but not sucrose self-administration history.
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DOI：
10.1016/j.neuroimage.2012.05.076
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发表时间：
2012-09
期刊：
影响因子：
5.7
通讯作者：
Stein, Elliot A.
中科院分区：
文献类型：
--
作者：
Lu, Hanbing;Chefer, Svetlana;Kurup, Pradeep K.;Guillem, Karine;Vaupel, D. Bruce;Ross, Thomas J.;Moore, Anna;Yang, Yihong;Peoples, Laura L.;Stein, Elliot A.
重复的可卡因暴露会诱导长期的神经适应，从而改变随后对药物的反应。然而，这些神经可塑性后果的系统水平的调查是有限的。我们采用啮齿动物模型的药物成瘾，以调查长期可卡因自我管理（SA）后，长期强迫禁欲相关的神经适应。由于自然奖励也激活中脑边缘奖励系统在一个部分重叠的方式作为可卡因，我们的设计还包括蔗糖SA组。训练大鼠使用固定比例的长期访问时间表（6小时/天，持续20天）自我管理可卡因或蔗糖。第三组未经处理的久坐大鼠作为阴性对照。戒断30天后，通过功能性磁共振成像（fMRI）评估静脉注射可卡因后奖赏系统的反应性。一个强有力的积极的功能磁共振成像反应，测量分数脑血容量变化相对于基线（CBV%），被认为是在久坐的对照组，如内侧前额叶皮质和前扣带皮质边缘区。相比之下，可卡因和蔗糖SA组表现出非常相似的初始阴性fMRI反应，随后是减弱的阳性反应。的mPFC反应的幅度显着相关的可卡因SA，但不为蔗糖SA组的训练课程期间的总摄入量的cancer。考虑到两个SA组具有相同的操作性训练和处理历史，回归分析显示的这种区域特异性组差异可能反映了与仅发生在可卡因SA动物中的成瘾样行为的出现特别相关的神经适应机制的发展。
Repeated cocaine exposure induces long-lasting neuroadaptations that alter subsequent responsiveness to the drug. However, systems-level investigation of these neuroplastic consequences is limited. We employed a rodent model of drug addiction to investigate neuroadaptations associated with prolonged forced abstinence after long-term cocaine self-administration (SA). Since natural rewards also activate the mesolimbic reward system in a partially over-lapping fashion as cocaine, our design also included a sucrose SA group. Rats were trained to self-administer cocaine or sucrose using a fixed-ratio one, long-access schedule (6 h/day for 20 days). A third group of naïve, sedentary rats served as a negative control. After 30 days of abstinence, the reactivity of the reward system was assessed with functional magnetic resonance imaging (fMRI) following an intravenous cocaine injection challenge. A strong positive fMRI response, as measured by fractional cerebral blood volume changes relative to baseline (CBV%), was seen in the sedentary control group in such cortico-limbic regions as medial prefrontal cortex and anterior cingulate cortex. In contrast, both the cocaine and sucrose SA groups demonstrated a very similar initial negative fMRI response followed by an attenuated positive response. The magnitude of the mPFC response was significantly correlated with the total amount of reinforcer intake during the training sessions for the cocaine SA but not for the sucrose SA group. Given that the two SA groups had identical histories of operant training and handling, this region-specific group difference revealed by regression analysis may reflect the development of neuroadaptive mechanisms specifically related to the emergence of addiction-like behavior that occurs only in cocaine SA animals.
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影响因子：
--
作者：
Hong, L. Elliot;Gu, Hong;Yang, Yihong;Ross, Thomas J.;Salmeron, Betty Jo;Buchholz, Brittany;Thaker, Gunvant K.;Stein, Elliot A.
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