Preparation and characterization of an electrospun colon-specific delivery system for salmon calcitonin.
Preparation and characterization of an electrospun colon-specific delivery system for salmon calcitonin.
复制标题
鲑鱼降钙素电纺结肠特异性输送系统的制备和表征
DOI：
10.1039/c8ra00385h
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发表时间：
2018-03-05
期刊：
影响因子：
3.9
通讯作者：
Wu, Hong
中科院分区：
文献类型：
--
作者：
Li, Chen;Wei, Yun-shan;Wen, Peng;Feng, Kun;Zong, Min-hua;Wu, Hong
为提高鲑鱼降钙素（SCT）的稳定性和生物利用度，研制了一种新型的结肠定位给药系统。首先采用薄膜分散法制备果胶包覆SCT脂质体，然后采用静电纺丝法制备脂质体/海藻酸钠/聚乙烯醇纤维毡。扫描电子显微镜分析表明，所得纳米纤维均匀光滑，平均直径约为350 nm。研究了SCT在不同模拟消化液中的释放，并建立了相应的释放动力学模型。结果表明，与未包被的SCT脂质体相比，含果胶包被的SCT脂质体的纤维毡具有更好的稳定性和结肠特异性，SCT在结肠中的释放遵循Case II转运机制。此外，通过ELISA测量释放的SCT的生物活性没有显著变化。本研究表明，电纺结肠定位纤维垫是一种潜在的生物活性肽的传递系统。
A novel electrospun colon-specific delivery system for salmon calcitonin (SCT) was developed to improve its stability and bioavailability. Firstly, the pectin-coated SCT liposomes were prepared by film dispersion method and then a liposomes/sodium alginate/polyvinyl alcohol fiber mat was fabricated by electrospining. Scanning electron microscopy analysis indicated that the obtained nanofibers were uniform and smooth with an average diameter of about 350 nm. The release of SCT in different simulated digestive fluids was studied and corresponding release kinetics models were built. It was found that the fiber mat containing pectin-coated SCT liposomes had better stability and colon-specific properties compared with that containing uncoated SCT liposomes and the release of SCT in the colon followed the case II transport mechanism. In addition, there is no significant change in the bioactivity of released SCT measured by ELISA. This study shows that the electrospun colon-specific fiber mat is a potential delivery system for bioactive peptides.
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DOI：
10.1016/j.ijfoodmicro.2017.11.019
发表时间：
2018-02-02
影响因子：
5.4
作者：
Cui, Haiying;Bai, Mei;Lin, Lin
通讯作者：
Lin, Lin
影响因子：
4.2
作者：
Saquing, Carl D.;Tang, Christina;Khan, Saad A.
通讯作者：
Khan, Saad A.
影响因子：
10.8
作者：
Thirawong, Nartaya;Thongborisute, Jringjai;Sriamornsak, Pornsak
通讯作者：
Sriamornsak, Pornsak
影响因子：
5.8
作者：
Sanko Nguyen;Alund, Siv Jorunn;Smistad, Gro
通讯作者：
Smistad, Gro
影响因子：
11.2
作者：
Cui, Haiying;Bai, Mei;Lin, Lin
通讯作者：
Lin, Lin