An All-In-One Transient Theranostic Platform for Intelligent Management of Hemorrhage.
An All-In-One Transient Theranostic Platform for Intelligent Management of Hemorrhage.
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DOI：
10.1002/advs.202301406
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发表时间：
2023-08
期刊：
影响因子：
15.1
通讯作者：
Zhu, Yangzhi
中科院分区：
文献类型：
--
作者：
Haghniaz, Reihaneh;Gangrade, Ankit;Montazerian, Hossein;Zarei, Fahimeh;Ermis, Menekse;Li, Zijie;Du, Yuxuan;Khosravi, Safoora;de Barros, Natan Roberto;Mandal, Kalpana;Rashad, Ahmad;Zehtabi, Fatemeh;Li, Jinghang;Dokmeci, Mehmet R.;Kim, Han-Jun;Khademhosseini, Ali;Zhu, Yangzhi
开发治疗诊断设备以在院前环境中检测出血并有效控制出血是一种未满足的医疗需求。本文提出了一种一体化治疗诊断平台，其通过将丝素蛋白（SF）固定在两个基于银纳米线（AgNW）的导电电极之间来构建，以非酶促诊断局部出血并在伤口部位止血。利用天然SF的止血特性，该器械由形状记忆SF海绵组成，促进血液凝固，与未经处理的血液相比，体外止血时间缩短约82%。此外，该夹层平台用作电容传感器，其可以检测出血并区分血液和其他体液（即，血清和水）。此外，AgNW电极还具有抗大肠杆菌和金黄色葡萄球菌感染的功效。此外，该器械显示出优异的生物相容性，并在体内逐渐生物降解，没有严重的局部或全身炎症反应。更重要的是，治疗诊断平台在大鼠肝出血模型中表现出与市售止血剂Dengen相当的止血功效。治疗诊断平台为出血的智能管理提供了一种未经探索的策略，通过整合诊断和治疗功能，有可能显著改善患者的健康状况。开发了一种新型生物相容性和生物可降解的一体化治疗诊断平台，用于感知和控制出血。该装置包括置于银纳米线（AgNW）电极之间的丝素蛋白（SF）海绵，所述电极充当电容传感器以检测出血并区分血液和其他体液。该器械的抗感染性能和止血效果与市售止血剂相当。
Developing theranostic devices to detect bleeding and effectively control hemorrhage in the prehospital setting is an unmet medical need. Herein, an all‐in‐one theranostic platform is presented, which is constructed by sandwiching silk fibroin (SF) between two silver nanowire (AgNW) based conductive electrodes to non‐enzymatically diagnose local bleeding and stop the hemorrhage at the wound site. Taking advantage of the hemostatic property of natural SF, the device is composed of a shape‐memory SF sponge, facilitating blood clotting, with ≈82% reduction in hemostatic time in vitro as compared with untreated blood. Furthermore, this sandwiched platform serves as a capacitive sensor that can detect bleeding and differentiate between blood and other body fluids (i.e., serum and water) via capacitance change. In addition, the AgNW electrode endows anti‐infection efficiency against Escherichia coli and Staphylococcus aureus. Also, the device shows excellent biocompatibility and gradually biodegrades in vivo with no major local or systemic inflammatory responses. More importantly, the theranostic platform presents considerable hemostatic efficacy comparable with a commercial hemostat, Dengen, in rat liver bleeding models. The theranostic platform provides an unexplored strategy for the intelligent management of hemorrhage, with the potential to significantly improve patients' well‐being through the integration of diagnostic and therapeutic capabilities. A novel biocompatible and biodegradable all‐in‐one theranostic platform is developed to sense and control bleeding. The device comprises a silk fibroin (SF) sponge placed between silver nanowire (AgNW) electrodes that act as a capacitive sensor to detect bleeding and differentiate between blood and other body fluids. The device demonstrates anti‐infection properties and hemostatic efficacy comparable to a commercial hemostat.
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影响因子：
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