Development of Silk Fibroin Scaffolds by Using Indirect 3D-Bioprinting Technology.
Development of Silk Fibroin Scaffolds by Using Indirect 3D-Bioprinting Technology.
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DOI：
10.3390/mi13010043
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发表时间：
2021-12-28
期刊：
影响因子：
3.4
通讯作者：
Lee H
中科院分区：
文献类型：
--
作者：
Choi YJ;Cho DW;Lee H
由于天然聚合物具有良好的生物相容性，各种天然聚合物已被广泛用作组织工程支架的生物材料。尽管天然聚合物具有良好的生物活性，但它们本身在制备具有足够机械强度的3D支架方面存在障碍。尽管多种3D-生物打印技术最近已经成为支架制备的有效制造工具，但仅使用具有可调机械性能的天然聚合物制备支架仍然是困难的。在这里，我们介绍了利用天然聚合物丝素蛋白通过间接3D生物打印技术制造支架的新方法。所研制的丝素支架具有良好的生物相容性和机械强度，可通过改变丝素浓度进行调节。此外，通过改变用于制备支架的丝素溶液的溶剂，可以控制丝素支架的柔韧性。因此，通过我们的方法制备的丝素蛋白支架可以考虑在软组织或肌肉骨骼组织的生物工程中的各种应用。
Due to the excellent biocompatibility of natural polymers, a variety of natural polymers have been widely used as biomaterials for manufacturing tissue engineered scaffolds. Despite the excellent biological activity of natural polymers, there have been obstacles in using them on their own to prepare 3D scaffolds with sufficient mechanical strength. Although multiple 3D-bioprinting technologies have recently emerged as effective manufacturing tools for scaffold preparation, scaffold preparation using only natural polymers with tunable mechanical properties is still difficult. Herein, we introduce novel scaffold fabrication methods using the natural polymer silk fibroin via indirect 3D-bioprinting technology. The developed silk fibroin scaffolds showed biocompatibility and tunable mechanical strength by changing the concentration of the silk fibroin. Furthermore, controlling the flexibility of the silk fibroin scaffolds was made possible by changing the solvent for the silk fibroin solution used to fabricate the scaffold. Consequently, silk fibroin scaffolds fabricated via our method can be considered for various applications in the bioengineering of either soft or musculoskeletal tissues.
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