Chromatin and beyond: the multitasking roles for SIRT6.
Chromatin and beyond: the multitasking roles for SIRT6.
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DOI：
10.1016/j.tibs.2013.12.002
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发表时间：
2014-02
影响因子：
13.8
通讯作者：
Mostoslavsky, Raul
中科院分区：
文献类型：
--
作者：
Kugel, Site;Mostoslavsky, Raul
近年来，我们对SIRT 6生物学的理解有了很大的扩展，包括其结构，调节，生化活性和生物学作用。SIRT 6作为乙酰基和长链脂肪酰基的ADP-核糖基化酶和NAD+依赖性脱酰酶发挥作用。通过这些功能，SIRT 6通过调节DNA修复、端粒维持以及葡萄糖和脂质代谢来影响细胞稳态，从而影响糖尿病、肥胖症、心脏病和癌症等疾病。这些作用可能有助于生物体的整体寿命和健康。直到最近，SIRT 6的大部分已知功能仅限于染色质。在这篇文章中，我们试图描述和扩展这方面的知识，了解SIRT 6作用机制及其对人类生物学和疾病的影响。
In recent years there has been a large expansion in our understanding of SIRT6 biology, including its structure, regulation, biochemical activity and biological roles. SIRT6 functions as an ADP-ribosylase and NAD+-dependent deacylase of both acetyl groups and long-chain fatty acyl groups. Through these functions SIRT6 impacts cellular homeostasis by regulating DNA repair, telomere maintenance and glucose and lipid metabolism, thus affecting diseases such diabetes, obesity, heart disease, and cancer. Such roles may contribute to overall longevity and health of the organism. Until recently, much of the known functions of SIRT6 were restricted to the chromatin. In this article, we seek to describe and expand this knowledge with recent advances in understanding the mechanisms of SIRT6 action and their implications for human biology and disease.
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影响因子：
64.8
作者：
Burnett, Camilla;Valentini, Sara;Cabreiro, Filipe;Goss, Martin;Somogyvari, Milan;Piper, Matthew D.;Hoddinott, Matthew;Sutphin, George L.;Leko, Vid;McElwee, Joshua J.;Vazquez-Manrique, Rafael P.;Orfila, Anne-Marie;Ackerman, Daniel;Au, Catherine;Vinti, Giovanna;Riesen, Michele;Howard, Ken;Neri, Christian;Bedalov, Antonio;Kaeberlein, Matt;Soti, Csaba;Partridge, Linda;Gems, David
通讯作者：
Gems, David
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影响因子：
3.5
作者：
Cai, Yi;Yu, Shan-Shan;Liu, Pei-Qing
通讯作者：
Liu, Pei-Qing
DOI：
10.1006/bbrc.2000.3000
发表时间：
2000-07-05
影响因子：
3.1
作者：
Frye, RA
通讯作者：
Frye, RA
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
64.5
作者：
Kawahara TL;Michishita E;Adler AS;Damian M;Berber E;Lin M;McCord RA;Ongaigui KC;Boxer LD;Chang HY;Chua KF
通讯作者：
Chua KF