Behavioral, Anatomical and Heritable Convergence of Affect and Cognition in Superior Frontal Cortex.
Behavioral, Anatomical and Heritable Convergence of Affect and Cognition in Superior Frontal Cortex.
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DOI：
10.1016/j.neuroimage.2021.118561
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发表时间：
2021-11
期刊：
影响因子：
5.7
通讯作者：
Valk SL
中科院分区：
文献类型：
--
作者：
Kraljević N;Schaare HL;Eickhoff SB;Kochunov P;Yeo BTT;Kharabian Masouleh S;Valk SL
认知能力和情感体验是人类在行为和大脑中相互关联的关键特征。认知和情感特征的个体差异，以及大脑结构，已经被证明是遗传效应的部分基础。然而，影响和认知在多大程度上与局部大脑结构有共同的遗传关系还不完全清楚。在这里，我们研究了行为和大脑结构(皮质厚度、表面积和皮质下体积)中认知和情感特征的表型和遗传相关性，在基于系谱的人类连接组项目样本(N=11091)中。认知和情感特质得分都具有高度的遗传性，并在行为水平上表现出显著的表型相关。左上额叶皮质厚度显示出与情感和认知的表型关联。将表型相关分解为遗传和环境成分表明，这些关联是由性状之间的共同遗传效应解释的。对左上额叶皮质的定量功能解码进一步表明，该区域与认知和情绪功能有关。这项研究提供了一个多层次的方法来研究情感和认知之间的联系，并认为两者在额叶上皮质厚度上是一致的。
Cognitive abilities and affective experience are key human traits that are interrelated in behavior and brain. Individual variation of cognitive and affective traits, as well as brain structure, has been shown to partly underlie genetic effects. However, to what extent affect and cognition have a shared genetic relationship with local brain structure is incompletely understood. Here we studied phenotypic and genetic correlations of cognitive and affective traits in behavior and brain structure (cortical thickness, surface area and subcortical volumes) in the pedigree-based Human Connectome Project sample (N = 1091). Both cognitive and affective trait scores were highly heritable and showed significant phenotypic correlation on the behavioral level. Cortical thickness in the left superior frontal cortex showed a phenotypic association with both affect and cognition. Decomposing the phenotypic correlations into genetic and environmental components showed that the associations were accounted for by shared genetic effects between the traits. Quantitative functional decoding of the left superior frontal cortex further indicated that this region is associated with cognitive and emotional functioning. This study provides a multi-level approach to study the association between affect and cognition and suggests a convergence of both in superior frontal cortical thickness.
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