Support cells in the brain promote longevity.
Support cells in the brain promote longevity.
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DOI：
10.1126/science.aba4474
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发表时间：
2020-01-24
期刊：
影响因子：
--
通讯作者：
Brunet A
中科院分区：
文献类型：
--
作者：
Miklas JW;Brunet A
Aging is a multifaceted process that results in organismal decay. At the cellular level, protein homeostasis is a key system that becomes dysregulated with age, causing the accumulation of aberrant or unfolded proteins. In a youthful individual, unfolded proteins normally trigger the unfolded protein response (UPR), which upregulates the protein clearance machinery and returns cells to a homeostatic state. The UPR is typically induced in a cell-autonomous manner. But some cells communicate protein folding stress to distal cells. For example, neurons communicate activation of the UPR to peripheral tissues to promote longevity in the wormCaenorhabditis elegans(1). On page 436 of this issue, Frakeset al.(2) show that support cells in the brain called glial cells (3) can also initiate long-range activation of the endoplasmic reticulum UPR (UPRER) in distal cells to coordinate stress resistance and longevity inC. elegansand that this occurs through neuropeptide secretion.
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1083/jcb.201010126
发表时间：
2011-05-02
期刊：
The Journal of cell biology
影响因子：
--
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作者：
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