A predictive model of the economic effects of an influenza vaccine adjuvant for the older adult (age 65 and over) population.

A predictive model of the economic effects of an influenza vaccine adjuvant for the older adult (age 65 and over) population.
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DOI:
10.1016/j.vaccine.2009.02.024
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发表时间:
2009-04-06
期刊:
影响因子:
5.5
通讯作者:
Smith KJ
Smith KJ
中科院分区:
医学3区
文献类型:
--
作者:
Lee BY;Ercius AK;Smith KJ

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免疫衰老降低流感疫苗在老年人(65岁及以上)中的效力。正在开发疫苗佐剂等策略来克服免疫衰老。我们的计算机模拟模型代表了给予老年人标准流感疫苗或含佐剂流感疫苗的决定,并发现含佐剂疫苗在许多情况下占主导地位,从而降低了成本并提高了有效性。在克服免疫衰老方面100%有效的佐剂疫苗仍然占主导地位,直到其成本超过标准疫苗成本65美元。在一个流感季节,佐剂将预防496,533例流感病例,171,981例住院治疗和70,429例死亡。
Immunosenescence decreases influenza vaccine efficacy in older adults (age 65 and over). Strategies such as vaccine adjuvants are being developed to overcome immunosenescence. Our computer simulation model represented the decision to give an older adult either standard influenza vaccine or adjuvanted influenza vaccine and found the adjuvanted vaccine to be dominant in many scenarios, resulting in lowered cost and greater effectiveness. An adjuvanted vaccine that is 100% effective in overcoming immunosenescence remained dominant until its cost exceeded the standard vaccine cost by $65. In a single influenza season, the adjuvant would prevent 496,533 influenza cases, 171,981 hospitalizations, and 70,429 deaths.
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