Childhood Adversity and the Association Between Stress Sensitivity and Problematic Alcohol Use in Adults.
Childhood Adversity and the Association Between Stress Sensitivity and Problematic Alcohol Use in Adults.
复制标题
童年逆境以及压力敏感性与成人酗酒问题之间的关联。
DOI：
10.1002/jts.22709
复制
发表时间：
2022-03
影响因子：
3.3
通讯作者：
Gorka S
中科院分区：
文献类型：
--
作者：
Hall OT;Phan KL;Gorka S
早期生活逆境（ELA）增加了酒精使用问题和酒精使用障碍（AUD）的风险。然而，目前还不清楚为什么一些但不是所有的ELA暴露的个人发展成问题的酒精使用。需要研究来确定这种环境风险因素如何与潜在的神经行为脆弱性相互作用，以解决酒精使用问题。对不确定威胁的超敏反应（U-威胁）已被假定为AUD的内表型，这可能有助于完善有问题的酒精使用的机制模型。因此，U-威胁超敏反应需要检查作为一个可能的个体差异因素，促进有问题的酒精使用之间的ELA暴露的个人。我们研究了ELA和U-威胁反应对问题饮酒和抑郁和焦虑症状严重程度的独特和交互作用。参与者（N = 131）完成了一个有效的休克威胁任务，并记录了惊吓眨眼增强指数厌恶反应。个人还完成了酒精使用，焦虑和抑郁症状的自我报告措施。结果表明，在高水平的U-威胁反应性下，ELA与高水平的问题酒精使用之间存在正相关，β =.75，t = 3.93，p < .001。相反，在低水平的U-威胁反应性下，ELA暴露与有问题的酒精使用呈负相关，β =-0.49，t =-2.30，p = 0.023。有没有显着的ELA × U-威胁反应性交互作用的焦虑或抑郁。U-威胁反应与ELA暴露强烈相互作用，影响ELA和问题饮酒之间的关联方向。U-威胁反应可能是一个有前途的目标，为预防和治疗有问题的饮酒之间的ELA暴露的个人。
Early life adversity (ELA) increases the risk of problematic alcohol use and alcohol use disorder (AUD). However, it is unclear why some but not all ELA-exposed individuals develop problematic alcohol use. Research is needed to determine how this environmental risk factor interacts with underlying neurobehavioral vulnerabilities to problem alcohol use. Hypersensitivity to uncertain threats (U-threat) has been posited as an endophenotype for AUD that might aid in the refinement of mechanistic models of problematic alcohol use. Therefore, U-threat hypersensitivity requires examination as a possible individual difference factor that facilitates problematic alcohol use among ELA-exposed individuals. We examined the unique and interactive effects of ELA and U-threat reactivity on problem drinking and depressive and anxiety symptom severity. Participants (N = 131) completed a well-validated threat-of-shock task, and startle eyeblink potentiation was recorded to index aversive responding. Individuals also completed self-report measures of alcohol use, anxiety, and depressive symptoms. Results demonstrated a positive association between ELA and higher levels of problematic alcohol use at high levels of U-threat reactivity, β =.75, t = 3.93, p < .001. Conversely, at low levels of U-threat reactivity, ELA exposure was negatively associated with problematic alcohol use, β = −.49, t = −2.30, p = .023. There was no significant ELA x U-Threat reactivity interaction on anxiety or depression. U-threat response strongly interacts with ELA exposure, affecting the direction of the association between ELA and problem drinking. U-threat reactivity may be a promising target for the prevention and treatment of problematic drinking among ELA-exposed individuals.
登录
查看更多内容
影响因子：
4.2
作者：
Clark, DB;De Bellis, MD;Martin, CS
通讯作者：
Martin, CS
影响因子：
5.1
作者：
Gibb, Brandon E.;Schofield, Casey A.;Coles, Meredith E.
通讯作者：
Coles, Meredith E.
DOI：
10.1097/00004583-199703000-00012
发表时间：
1997-03-01
影响因子：
13.3
作者：
Bernstein, DP;Ahluvalia, T;Handelsman, L
通讯作者：
Handelsman, L
影响因子：
6.6
作者：
Dunn EC;Nishimi K;Gomez SH;Powers A;Bradley B
通讯作者：
Bradley B
影响因子：
4.8
作者：
Bernstein, DP;Stein, JA;Zule, W
通讯作者：
Zule, W