Effect of exercise training and dopamine agonists in patients with uremic restless legs syndrome: a six-month randomized, partially double-blind, placebo-controlled comparative study.
Effect of exercise training and dopamine agonists in patients with uremic restless legs syndrome: a six-month randomized, partially double-blind, placebo-controlled comparative study.
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DOI：
10.1186/1471-2369-14-194
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发表时间：
2013-09-11
期刊：
影响因子：
2.3
通讯作者：
Stefanidis I
中科院分区：
文献类型：
--
作者：
Giannaki CD;Sakkas GK;Karatzaferi C;Hadjigeorgiou GM;Lavdas E;Kyriakides T;Koutedakis Y;Stefanidis I
不宁腿综合征在血液透析患者中非常常见，但目前还没有比较研究评估非药物治疗与经典治疗在综合征严重程度和生活质量相关参数上的有效性。在这项随机、部分双盲、安慰剂对照试验中，32例患有不宁腿综合征的血液透析患者随机分为三组：1)运动训练组（N = 16）， 2)多巴胺激动剂组（罗匹尼罗0.25 mg/d） （N = 8）和3)安慰剂组（N = 8）。干预项目持续6个月。使用国际严重程度量表评估不宁腿综合征的严重程度，通过一系列测试评估身体表现，通过计算机断层扫描评估肌肉大小和组成，通过双能X射线吸收仪评估身体组成，通过问卷调查评估抑郁评分、睡眠质量、日常嗜睡和生活质量。运动训练和多巴胺激动剂分别能有效减轻46% （P = 0.009）和54% （P = 0.001）的综合征症状。组内变化显示两种方法均显著改善了生活质量（P < 0.05），但只有多巴胺激动剂显著改善了睡眠质量（P = 0.009）。在组内的变化中，多巴胺激动剂有改善瘦体质量的趋势，这只与运动训练有统计学意义（P = 0.014），在各项测试中，运动训练也减少了肌肉中的脂肪浸润（P = 0.044），提高了身体机能（P > 0.05）。在组间变化中，运动和多巴胺激动剂均显著改善抑郁评分（P = 0.003），而与运动和安慰剂相比，只有多巴胺激动剂治疗能够显著改善睡眠质量（P = 0.016）。在减少尿毒症患者不宁腿综合征症状和改善抑郁评分方面，6个月的运动训练方案与6个月的低剂量多巴胺激动剂治疗同样有效。为了证明联合治疗是否更有利于改善RLS，还需要进一步的研究。NCT00942253
Restless Legs Syndrome is very common in hemodialysis patients however there are no comparative studies assessing the effectiveness of a non-pharmacological treatment to a classical treatment on parameters related to syndromes’ severity and quality of life. In this randomized, partially double blind, placebo controlled trial, thirty two hemodialysis patients with restless legs syndrome were randomly assigned into three groups: 1) the exercise training group (N = 16), 2) the dopamine agonists group (ropinirole 0.25 mg/d) (N = 8) and 3) the placebo group (N = 8). The intervention programs lasted 6 months. Restless Legs Syndrome severity was assessed using the international severity scale, physical performance by a battery of tests, muscle size and composition by computed tomography, body composition by Dual Energy X Ray Absorptiometry, while depression score, sleep quality, daily sleepiness and quality of life were assessed through questionnaires. Exercise training and dopamine agonists were effective in reducing syndrome’s symptoms by 46% (P = 0.009) and 54% (P = 0.001) respectively. Within group changes revealed that both approaches significantly improved quality of life (P < 0.05), however, only the dopamine agonists significantly improved sleep quality (P = 0.009). Within group changes showed a tendency for lean body mass improvements with dopamine agonists, this reached statistical significance only with the exercise training (P = 0.014), which also reduced fat infiltration in muscles (P = 0.044) and improved physical performance (P > 0.05) in various tests. Between group changes detect significant improvements with both exercise and dopamine agonists in depression score (P = 0.003), while only the dopamine agonist treatment was able to significantly improve sleep quality, compared to exercise and placebo (P = 0.016). A 6-month exercise training regime was as effective as a 6-month low dosage dopamine agonist treatment in reducing restless legs syndrome symptoms and improving depression score in uremic patients. Further research is needed in order to show whether a combination treatment could be more beneficial for the amelioration of RLS. NCT00942253
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影响因子：
3.7
作者：
Giannaki CD;Sakkas GK;Karatzaferi C;Hadjigeorgiou GM;Lavdas E;Liakopoulos V;Tsianas N;Koukoulis GN;Koutedakis Y;Stefanidis I
通讯作者：
Stefanidis I
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6.1
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