IL-11 is a parietal cell cytokine that induces atrophic gastritis.
IL-11 is a parietal cell cytokine that induces atrophic gastritis.
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DOI：
10.1136/gutjnl-2011-300539
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发表时间：
2012-10
期刊：
影响因子：
24.5
通讯作者：
Judd LM
中科院分区：
文献类型：
--
作者：
Howlett M;Chalinor HV;Buzzelli JN;Nguyen N;van Driel IR;Bell KM;Fox JG;Dimitriadis E;Menheniott TR;Giraud AS;Judd LM
白细胞介素在胃损伤、粘膜修复和胃癌进展中起重要作用。我们分析了幽门螺杆菌感染小鼠胃中IL-11的表达、小鼠和人胃中IL-11的表达部位以及外源性IL-11对胃黏膜稳态的影响。IL-11蛋白在小鼠和人胃中均有定位。通过基因芯片检测慢性外源性IL-11对正常小鼠胃的组织学和转录的影响，并通过mRNA和蛋白分析证实。测定IL-11对胃酸分泌的功能影响。在感染幽门螺杆菌的小鼠中，IL-11在基底粘膜中升高，其颞叶表达与IL-1b相似。IL-11蛋白主要定位于小鼠和人胃壁细胞。外源性IL-11的应用导致基底壁细胞和主细胞的损失、增生、粘膜细胞化生和炎症。与细胞变化相一致的是胃pH值升高，壁细胞超微结构改变和基因表达改变，特别是涉及免疫反应和离子运输的基因，这可能导致酸分泌受损。我们证实单剂量IL-11有效地消除了胃对组胺的反应。IL-11是一种壁细胞细胞因子，可能通过降低壁细胞离子转运基因、CCKb和组胺H2受体的表达来阻断胃酸分泌。IL-11在幽门螺杆菌感染的小鼠胃中表达增加，IL-11治疗野生型小鼠胃底黏膜的变化使人联想到慢性萎缩性胃炎（胃癌的前体）。
IL-is important in gastric damage, mucosal repair and gastric cancer progression. We analysed IL-11 expression in H.pylori infected mouse stomach, the site of gastric IL-11 expression in mice and humans, and the effect of exogenous IL-11 on gastric mucosal homeostasis. IL-11 protein was localised in mouse and human stomach. The impact of chronic, exogenous IL-11 on normal mouse stomach was examined Histologically and transcriptionally by microarray, confirmed by mRNA and protein analysis. Functional impact of IL-11 on gastric acid secretion was determined. In mice infected with H.pylori, IL-11 was increased in fundic mucosa with temporal expression similar to IL-1b. IL-11 protein was localised predominantly to parietal cells in mouse and human stomach. Application of exogenous IL-11 to resulted in fundic parietal and chief cell loss, hyperplasia, mucous cell metaplasia and inflammation. Coincident with cellular changes were an increased gastric pH, altered parietal cell ultrastructure and altered gene expression, particularly genes involved in immune response and ion transport which could result in compromised acid secretion. We confirmed that a single dose of IL-11 effectively ablated the gastric response to histamine. IL-11 is a parietal cell cytokine that blocks gastric acid secretion, likely via reducing expression of parietal cell ion transport genes, CCKb and histamine H2 receptors. IL-11 expression is increased in H. pylori infected mouse stomach and treatment of wild type mice with IL-11 induced changes in the gastric fundic mucosa reminiscent of chronic atrophic gastritis, a precursor to gastric cancer.
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影响因子：
2.6
作者：
Holmes K;Egan B;Swan N;O'Morain C
通讯作者：
O'Morain C
影响因子：
1.8
作者：
Fujisawa, T;Kamimura, H;Takeuchi, T
通讯作者：
Takeuchi, T
影响因子：
29.4
作者：
Howlett, M;Judd, LM;Giraud, AS
通讯作者：
Giraud, AS
DOI：
10.1152/ajpgi.00382.2006
发表时间：
2007-01-01
影响因子：
4.5
作者：
Giraud, A. S.;Jackson, C.;Judd, L. M.
通讯作者：
Judd, L. M.
影响因子：
9.8
作者：
Chourasia, Dipti;Achyut, B. R.;Ghoshal, Uday C.
通讯作者：
Ghoshal, Uday C.