A Very-Low-Calorie Diet Can Cause Remission of Diabetes Mellitus and Hypertriglyceridemia in Familial Partial Lipodystrophy.
A Very-Low-Calorie Diet Can Cause Remission of Diabetes Mellitus and Hypertriglyceridemia in Familial Partial Lipodystrophy.
复制标题
作者：
没有强有力的证据表明任何特定的饮食是脂肪代谢障碍综合征的首选治疗方法。在这里，我们评论的好处，极低热量饮食（VLCD）的患者与家族性部分脂肪营养不良2型（FPLD 2）。一名38岁女性，诊断为FPLD 2，有多种合并症病史，接受了16周的VLCD，短期目标是快速改善其代谢状态，以通过体外受精（IVF）实现妊娠。我们观察到体重减少12.3 kg，血红蛋白A1 c减少1.4%。胰岛素（-33.2%）、甘油三酯（-40.7%）和游离脂肪酸（-34%）曲线下面积的下降非常显著。全身脂肪减少16%，肝脏脂肪减少80%。她在IVF期间的卵子回收率和质量远远上级过去的过度刺激。我们的数据鼓励使用这种医疗方法的其他患者类似的代谢和生殖异常，由于脂肪组织不足。
There is no strong evidence that any specific diet is the preferred treatment for lipodystrophy syndromes. Here we remark on the benefits of a very-low-calorie diet (VLCD) in a patient with familial partial lipodystrophy type 2 (FPLD2). A 38-year-old female diagnosed with FPLD2, with a history of multiple comorbidities, underwent 16 weeks of VLCD with a short-term goal of improving her metabolic state rapidly to achieve pregnancy by in vitro fertilization (IVF). We observed a reduction of 12.3 kg in body weight and 1.4% in hemoglobin A1c. The decrease in the area under the curves of insulin (−33.2%), triglycerides (−40.7%), and free fatty acids (−34%) were very remarkable. Total body fat was reduced by 16%, and liver fat by 80%. Her egg retrieval rate and quality during IVF were far superior to past hyperstimulation. Our data encourage the use of this medical approach for other patients with similar metabolic and reproductive abnormalities due to adipose tissue insufficiency.
登录
查看更多内容
脂肪营养不良综合征的诊断和管理：多社会实践指南。
DOI：
10.1210/jc.2016-2466
发表时间：
2016-12
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Brown RJ;Araujo-Vilar D;Cheung PT;Dunger D;Garg A;Jack M;Mungai L;Oral EA;Patni N;Rother KI;von Schnurbein J;Sorkina E;Stanley T;Vigouroux C;Wabitsch M;Williams R;Yorifuji T
通讯作者：
Yorifuji T
影响因子：
6
作者：
Fernandez-Pombo, Antia;Diaz-Lopez, Everardo Josue;Castro, Ana I.;Sanchez-Iglesias, Sofia;Cobelo-Gomez, Silvia;Prado-Morana, Teresa;Araujo-Vilar, David
通讯作者：
Araujo-Vilar, David
影响因子：
9.8
作者：
ROBBINS, DC;DANFORTH, E;SIMS, EAH
通讯作者：
SIMS, EAH
影响因子：
5.9
作者：
Ožvald I;Božičević D;Duh L;Vinković Vrček I;Pavičić I;Domijan AM;Milić M
通讯作者：
Milić M
影响因子：
16.2
作者：
Steven, Sarah;Hollingsworth, Kieren G.;Taylor, Roy
通讯作者：
Taylor, Roy