Effects of a 3-Week Hospital-Controlled Very-Low-Calorie Diet in Severely Obese Patients.
Effects of a 3-Week Hospital-Controlled Very-Low-Calorie Diet in Severely Obese Patients.
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DOI：
10.3390/nu13124468
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发表时间：
2021-12-14
期刊：
影响因子：
5.9
通讯作者：
Milić M
中科院分区：
文献类型：
--
作者：
Ožvald I;Božičević D;Duh L;Vinković Vrček I;Pavičić I;Domijan AM;Milić M
尽管极低热量饮食 (VLCD) 被认为是安全的，并且已证明其优于其他类型的饮食，但有关其对改善严重肥胖患者健康和减肥效果的数据却很少。作为克罗地亚 Duga Resa 长期治疗特别医院开发的个性化减肥计划的一部分，我们在使用 567 kcal、医院控制的 VLCD 治疗 3 周后，对严重肥胖患者 (BMI ≥ 35 kg m−2) 进行了人体测量、生化和永久性 DNA 损伤参数（通过细胞松弛素 B 阻断的微核细胞测定 — CBMN 进行评估）进行了评估。这是第一项针对此类 VLCD 患者基因组永久性（不稳定）稳定性的研究。 VLCD 导致体重、血脂参数、尿素、胰岛素抵抗和还原型谷胱甘肽 (GSH) 显着下降。基因组不稳定参数降低了一半，达到了健康人群中通常存在的参考值。研究发现 GSH 减少与 DNA 损伤减少之间存在相关性。 VLCD 显示易感个体仍具有较高的 DNA 损伤，以便进一步监测。在由 26 名肥胖患者组成的高度异质性组（肥胖 II 级和 III 级、体重、BMI 和其他类别的差异）中，该方法证明了其在健康改善方面的有用性和益处，使得基于不断变化的人体测量/生化 VLCD 参数和 CBMN 结果的个体方法能够进一步监测、诊断、治疗和风险评估。
Although a very-low-calorie diet (VLCD) is considered safe and has demonstrated benefits among other types of diets, data are scarce concerning its effects on improving health and weight loss in severely obese patients. As part of the personalized weight loss program developed at the Duga Resa Special Hospital for Extended Treatment, Croatia, we evaluated anthropometric, biochemical, and permanent DNA damage parameters (assessed with the cytochalasin B-blocked micronucleus cytome assay—CBMN) in severely obese patients (BMI ≥ 35 kg m−2) after 3-weeks on a 567 kcal, hospital-controlled VLCD. This is the first study on the permanent genomic (in)stability in such VLCD patients. VLCDs caused significant decreases in weight (loss), parameters of the lipid profile, urea, insulin resistance, and reduced glutathione (GSH). Genomic instability parameters were lowered by half, reaching reference values usually found in the healthy population. A correlation was found between GSH decrease and reduced DNA damage. VLCDs revealed susceptible individuals with remaining higher DNA damage for further monitoring. In a highly heterogeneous group (class II and III in obesity, differences in weight, BMI, and other categories) consisting of 26 obese patients, the approach demonstrated its usefulness and benefits in health improvement, enabling an individual approach to further monitoring, diagnosis, treatment, and risk assessment based on changing anthropometric/biochemical VLCD parameters, and CBMN results.
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影响因子：
2.9
作者：
Kamencic, H;Lyon, A;Juurlink, BHJ
通讯作者：
Juurlink, BHJ
影响因子：
64.8
作者：
Kahn, Steven E.;Hull, Rebecca L.;Utzschneider, Kristina M.
通讯作者：
Utzschneider, Kristina M.
影响因子：
3.6
作者：
Himbert, Caroline;Thompson, Henry;Ulrich, Cornelia M.
通讯作者：
Ulrich, Cornelia M.
DOI：
10.1093/jnci/djx012
发表时间：
2017-09-01
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Carreras-Torres R;Johansson M;Gaborieau V;Haycock PC;Wade KH;Relton CL;Martin RM;Davey Smith G;Brennan P
通讯作者：
Brennan P
影响因子：
4.1
作者：
Alemán JO;Iyengar NM;Walker JM;Milne GL;Da Rosa JC;Liang Y;Giri DD;Zhou XK;Pollak MN;Hudis CA;Breslow JL;Holt PR;Dannenberg AJ
通讯作者：
Dannenberg AJ