Similarities and differences in gut microbiome composition correlate with dietary patterns of Indian and Chinese adults.
Similarities and differences in gut microbiome composition correlate with dietary patterns of Indian and Chinese adults.
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DOI：
10.1186/s13568-018-0632-1
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发表时间：
2018-06-23
期刊：
影响因子：
3.7
通讯作者：
Chen WN
中科院分区：
文献类型：
--
作者：
Jain A;Li XH;Chen WN
饮食和肠道微生物群之间的相互作用，以及最终与健康的联系，已经成为大量研究的焦点。然而，这种关系仍然需要充分表征，特别是在亚洲人群中。我们使用IlluminaHiSeq 2500平台上的下一代测序分析，比较了22-35岁健康印度和中国成年人的粪便细菌多样性和组成。我们的分析揭示了独特的社区结构，占主导地位的厚壁菌门，放线菌和代表不足拟杆菌，印度和中国的肠道细菌。这种群落结构与俄罗斯人口的肠道细菌组成密切匹配。因此，我们假设这些细菌分支的富集是由高消费的富含淀粉的饮食如大米，马铃薯，精制谷物支持的。双歧杆菌属的优势，由于碳水化合物丰富的饮食是本研究的另一个显着特点。此外，与中国人相比，印度肠道细菌主要由拟杆菌属（p = 0.001）和普雷沃菌属（p = 0.002）代表，这可能与印度人的全谷物和植物性素食有关。印度成年人肠道菌群的多样性与中国成年人相同（p > 0.1），但在肠道菌群组成和相对丰度上存在显著差异（R = 0.625，p < 0.005）。偏最小二乘判别分析和非度量多维标度图显示饮食习惯明智的主题聚类。因此，目前的工作证实了饮食在确定肠道细菌组成中的重要作用。LEfse分析表明，普雷沃氏菌属、巨球菌属、链杆菌属、乳杆菌属、瘤胃球菌属和鸡眼普雷沃氏菌属、瘤胃乳杆菌属是潜在的膳食生物标志物。本文的在线版本（10.1186/s13568-018-0632-1）包含补充材料，可供授权用户使用。
The interaction between diet and gut microbiota, and ultimately their link to health, has turned into the concentration of huge research. However, this relationship still needs to be fully characterized, particularly in case of the Asian population. We compared the fecal bacterial diversity and composition of healthy Indian and Chinese adults, ages 22–35 years, using next-generation sequencing analysis on IlluminaHiSeq 2500 platform. Our analysis revealed unique community structure, dominant Firmicutes, Actinobacteria and underrepresented Bacteroides, of Indian and Chinese gut bacteria. This community structure closely matched with the gut bacterial composition of the Russian population. Therefore, we hypothesized that enrichment of these bacterial clades is supported by high consumption of starch-rich diet such as rice, potato, refined grains. The dominance of genus Bifidobacterium due to carbohydrate-rich diet is another notable feature of this study. Moreover, Indian gut bacteria are significantly represented by Bacteroidetes (p = 0.001) and Prevotella (p = 0.002) in contrast to Chinese, which could be associated with whole grains and plant-based vegetarian diet of Indians. The gut bacterial population of Indian adults were as diverse as Chinese adults (p > 0.1), but significant difference was noticed in gut bacterial composition and relative abundance between two populations (R = 0.625, p < 0.005). Partial least squares discriminant analysis and non-metric multidimensional scaling plots showed dietary habit wise clustering of subjects. Thus, the present work confirms an important role of diet in determining gut bacterial composition. LEfse analysis revealed genera Prevotella, Megasphaera, Catenibacterium, Lactobacillus, Ruminococcus and species Prevotella copri, Lactobacillus ruminis as the potential biomarkers of diet. The online version of this article (10.1186/s13568-018-0632-1) contains supplementary material, which is available to authorized users.
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