Validity of Normative Volumetric Estimates from Open Access Software in Amnestic Mild Cognitive Impairment.
Validity of Normative Volumetric Estimates from Open Access Software in Amnestic Mild Cognitive Impairment.
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DOI：
10.14283/jpad.2023.19
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发表时间：
2023
影响因子：
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阿尔茨海默病（AD）中的神经变性通常通过脑MRI评估。虽然专有软件可以提供区域萎缩的规范性估计，这种工具可能是成本高昂的研究设置。用于生成规范性估计的免费软件最近已经发布，但尚未在遗忘型轻度认知障碍（aMCI）的背景下进行验证。确定从开源软件生成的规范性形态测量估计是否复制了aMCI中神经退行性变的既定模式，以及这些指标是否与情景记忆表现相关。在老化和aMCI中进行的脑MRI和认知的观察性研究，两次相同的研究访视间隔约1.2年。参与者从当地社区和门诊临床环境中招募。患有aMCI的60-85岁成人（n = 25）和认知正常对照（CN; n = 74）。一个子集返回进行随访（aMCI n = 11，CN n = 52）。参与者完成了大脑MRI和两项言语情景记忆的神经心理学测试。使用FreeSurfer v6.0和Normative Morphometry Image Statistics生成AD相关区域（海马、海马旁、内嗅皮层、杏仁核）和对照区域（楔叶、舌回、距周回）的标准形态测量估计值，并根据年龄、性别、头部尺寸、扫描仪制造商和场强进行调整。我们测试了ROI体积和记忆的基线组差异，并评估了它们的组内关联。我们还评估了ROI体积随时间的变化，并测试了这些变化是否与记忆力下降相对应。基线时，aMCI组的记忆力较差，AD相关区域的体积小于CN组。对照区体积无组间差异。记忆仅与aMCI组中AD相关区域的体积相关。aMCI组海马体积（17% vs. 8%年下降）和内嗅体积（54% vs. 5%年下降）的下降幅度大于CN组。海马体积的减少与aMCI组的记忆力下降略微相关。从免费提供的软件生成的规范形态测量值显示了AD相关体积和记忆关联的组差异的预期模式。显著的影响局限于AD相关的脑区，仅发生在aMCI组。这些研究结果支持这些免费工具的有效性，作为在研究环境中使用的专有软件的可靠和具有成本效益的替代品。
Neurodegeneration in Alzheimer’s disease (AD) is typically assessed through brain MRI. Although proprietary software can provide normative estimates of regional atrophy, such tools can be cost-prohibitive for research settings. Free software for generating normative estimates has recently been released but has yet to be validated in the context of amnestic mild cognitive impairment (aMCI). Determine whether normative morphometric estimates generated from open-source software replicate established patterns of neurodegeneration in aMCI, and whether these metrics correlate with episodic memory performance. Observational study of brain MRI and cognition in aging and aMCI with two identical study visits occurring approximately 1.2 years apart. Participants were recruited from the local community and outpatient clinical settings. Adults ages 60–85 with aMCI (n = 25) and cognitively normal controls (CN; n = 74). A subset returned for follow-up (aMCI n = 11, CN n = 52). Participants completed brain MRI and two neuropsychological tests of verbal episodic memory. FreeSurfer v6.0 and Normative Morphometry Image Statistics were used to generate normative morphometric estimates for AD-relevant regions (hippocampus, parahippocampus, entorhinal cortex, amygdala) and control regions (cuneus, lingual gyrus, pericalcarine gyrus), adjusting for age, sex, head size, scanner manufacturer, and field strength. We tested for baseline group differences in ROI volumes and memory and assessed their within-group associations. We also evaluated changes in ROI volumes over time and tested whether these changes corresponded to declines in memory. At baseline, the aMCI group exhibited poorer memory and smaller volumes in AD-relevant regions than the CN group. There were no group differences in control region volumes. Memory was associated with volumes in AD-relevant regions in the aMCI group only. The aMCI group exhibited greater declines than the CN group in hippocampal volume (17% vs. 8% annual decline) and entorhinal volume (54% vs. 5% annual decline). Decrease in hippocampal volume was marginally associated with decline in memory for the aMCI group. Normative morphometric values generated from freely available software demonstrated expected patterns of group differences in AD-related volumes and associations with memory. Significant effects were localized to AD-relevant brain regions and only occurred in the aMCI group. These findings support the validity of these free tools as reliable and cost-effective alternatives to proprietary software for use in research settings.
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DOI：
10.1523/jneurosci.3252-09.2009
发表时间：
2009-12-02
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
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作者：
Fjell AM;Walhovd KB;Fennema-Notestine C;McEvoy LK;Hagler DJ;Holland D;Brewer JB;Dale AM
通讯作者：
Dale AM
影响因子：
4.2
作者：
Benitez A;Jensen JH;Falangola MF;Nietert PJ;Helpern JA
通讯作者：
Helpern JA
影响因子：
2.3
作者：
Ross, David E.;Ochs, Alfred L.;Bigler, Erin D.
通讯作者：
Bigler, Erin D.
影响因子：
2.3
作者：
Sexton, Claire E.;Mackay, Clare E.;Ebmeier, Klaus P.
通讯作者：
Ebmeier, Klaus P.
DOI：
10.1097/jgp.0b013e31819431d5
发表时间：
2009-05
期刊：
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
影响因子：
--
作者：
Jak AJ;Bondi MW;Delano-Wood L;Wierenga C;Corey-Bloom J;Salmon DP;Delis DC
通讯作者：
Delis DC