HLA-A alleles and the risk of cervical squamous cell carcinoma in Japanese women.
HLA-A alleles and the risk of cervical squamous cell carcinoma in Japanese women.
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DOI：
10.2188/jea.je20090155
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发表时间：
2010
影响因子：
4.7
通讯作者：
Tanaka H
中科院分区：
文献类型：
--
作者：
Hosono S;Kawase T;Matsuo K;Watanabe M;Kajiyama H;Hirose K;Suzuki T;Kidokoro K;Ito H;Nakanishi T;Yatabe Y;Hamajima N;Kikkawa F;Tajima K;Tanaka H
我们进行了一项病例对照研究，以探讨人类白细胞抗原-A（HLA-A）等位基因多态性与日本妇女宫颈肿瘤发病机制之间的关系。共有119例浸润性宫颈鳞状细胞癌患者与119例年龄和绝经状态匹配的非癌症对照进行了比较。从所有病例和对照组中采集血液样本，并通过自填式问卷收集生活方式信息。非条件Logistic回归模型评估HLA-A等位基因对宫颈癌风险的估计影响。病例组HLA-A*0206的频率显著低于对照组（P = 0.006）。A*0206与宫颈癌风险呈负相关（比值比[OR] = 0.31，95%置信区间[95% CI] = 0.15至0.65，P = 0.002），而HLA-A*2402与宫颈癌风险呈正相关（OR = 1.76，95% CI = 1.00至3.09，P = 0.048）。经多重比较校正后，A*0206与宫颈癌风险降低显著相关（校正P = 0.036）。此外，A*0206与宫颈癌风险之间的负相关性与吸烟状态无关（从不吸烟：OR = 0.37，95% CI = 0.15 - 0.90;曾经吸烟：OR = 0.23，95% CI = 0.06 - 0.89）。在日本女性中，HLA-A*0206与宫颈癌风险呈负相关，这表明HLA-A多态性影响宫颈癌风险。因此，需要在其他人群中进行进一步研究。
We conducted a case-control study to examine the relationship between human leukocyte antigen-A (HLA-A) allele polymorphism and the pathogenesis of cervical neoplasia among Japanese women. A total of 119 patients with invasive cervical squamous cell carcinoma were compared to 119 age- and menopausal status-matched non-cancer controls. Blood samples were taken from all cases and controls and lifestyle information was collected by means of a self-administered questionnaire. The estimated impact of HLA-A alleles on cervical cancer risk was evaluated by unconditional logistic regression models. The frequency of HLA-A*0206 among cases was significantly lower than among controls (P = 0.006). There was an inverse association between A*0206 and cervical cancer risk (odds ratio [OR] = 0.31, 95% confidence interval [95% CI] = 0.15 to 0.65, P = 0.002), and a positive association for HLA-A*2402 (OR = 1.76, 95% CI = 1.00 to 3.09, P = 0.048). After correction for multiple comparisons, A*0206 was significantly associated with reduced cervical cancer risk (corrected P = 0.036). Furthermore, the inverse association between A*0206 and cervical cancer risk was independent of smoking status (never smoker: OR = 0.37, 95% CI = 0.15 to 0.90; ever smoker: OR = 0.23, 95% CI = 0.06 to 0.89). There was an inverse association between HLA-A*0206 and cervical cancer risk among Japanese women, which suggests that HLA-A polymorphism influences cervical cancer risk. Further investigation in other populations is thus warranted.
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Koopman, LA;Mulder, A;Fleuren, GJ
通讯作者：
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