Epigallocatechin-3-gallate ameliorates radiation-induced acute skin damage in breast cancer patients undergoing adjuvant radiotherapy.
Epigallocatechin-3-gallate ameliorates radiation-induced acute skin damage in breast cancer patients undergoing adjuvant radiotherapy.
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表没食子儿茶素-3-没食子酸酯可改善接受辅助放疗的乳腺癌患者辐射引起的急性皮肤损伤。
DOI：
10.18632/oncotarget.9495
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发表时间：
2016-07-26
期刊：
影响因子：
--
通讯作者：
Zheng M
中科院分区：
文献类型：
--
作者：
Zhu W;Jia L;Chen G;Zhao H;Sun X;Meng X;Zhao X;Xing L;Yu J;Zheng M
对于乳腺癌患者的放射性皮炎，几乎没有有效的治疗选择。我们进行了一项单臂试验，以验证外用没食子儿茶素-3-没食子酸酯（EGCG）对接受放疗的乳腺癌患者放射性皮炎有效的假设。49名患者参与了这项研究。患者行乳房切除术后辅助放疗。每日局部应用EGCG，从出现I级皮炎开始，至放疗后两周结束。EGCG治疗期间观察到的最大皮炎如下：1级毒性，71.4%（35例）；2级毒性，28.6%（14例）；没有3级或4级毒性的患者。大多数放射性皮炎发生在放疗结束后1周。EGCG减轻了85.7%的患者的疼痛，89.8%的患者减轻了烧灼感，87.8%的患者减轻了瘙痒，71.4%的患者减轻了牵拉，79.6%的患者减轻了压痛。这些发现表明外用EGCG可能是治疗放射性皮炎的有效方法，并且具有可接受的毒性。
There are few effective treatment options for radiation-induced dermatitis in breast cancer patients. We conducted a single-arm trial to tested the hypothesis that topical epigallocatechin-3-gallate (EGCG) is effective against radiation-induced dermatitis in breast cancer patients undergoing radiotherapy. Forty-nine patients participated in this study. The patients underwent mastectomy followed by adjuvant radiotherapy. Topical EGCG was applied daily, starting when grade I dermatitis appeared and ending two weeks after radiotherapy. The maximum dermatitis observed during the EGCG treatment was as follows: Grade 1 toxicity, 71.4% (35 patients); grade 2 toxicity, 28.6% (14 patients); there were no patients with grade 3 or 4 toxicity. The majority of the radiation-induced dermatitis was observed 1 week after the end of radiotherapy. EGCG reduced the pain in 85.7% of patients, burning-feeling in 89.8%, itching in 87.8%, pulling in 71.4%, and tenderness in 79.6%. These findings suggest topical EGCG may be an effective treatment for radiation-induced dermatitis and has acceptable toxicity.
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