Mesenchymal stem cells isolated from adipose and other tissues: basic biological properties and clinical applications.

Mesenchymal stem cells isolated from adipose and other tissues: basic biological properties and clinical applications.
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从脂肪和其他组织分离的间充质干细胞:基本的生物学特性和临床应用。

DOI:
10.1155/2012/461718
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发表时间:
2012
影响因子:
4.3
通讯作者:
Mizuno H
Mizuno H
中科院分区:
医学3区
文献类型:
--
作者:
Orbay H;Tobita M;Mizuno H

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间充质干细胞(MSC)是最初从骨髓中分离的成体干细胞。然而,随后的研究表明,其他成人组织也含有MSC。间充质干细胞起源于间充质,间充质是来源于中胚层的胚胎组织。这些细胞活跃地增殖,在某些组织中产生新细胞,但在其他组织中保持静止。MSC能够分化成多种细胞类型,包括脂肪细胞、软骨细胞、骨细胞和心肌细胞。这些细胞的分离和诱导可以为替代受损或丢失的成人组织提供新的治疗工具。然而,在获得显著的临床益处之前,必须充分建立干细胞的生物学特性和在临床环境中的使用。本文总结了骨髓间充质干细胞的生物学特性的数据,并讨论了目前和潜在的临床应用。
Mesenchymal stem cells (MSCs) are adult stem cells that were initially isolated from bone marrow. However, subsequent research has shown that other adult tissues also contain MSCs. MSCs originate from mesenchyme, which is embryonic tissue derived from the mesoderm. These cells actively proliferate, giving rise to new cells in some tissues, but remain quiescent in others. MSCs are capable of differentiating into multiple cell types including adipocytes, chondrocytes, osteocytes, and cardiomyocytes. Isolation and induction of these cells could provide a new therapeutic tool for replacing damaged or lost adult tissues. However, the biological properties and use of stem cells in a clinical setting must be well established before significant clinical benefits are obtained. This paper summarizes data on the biological properties of MSCs and discusses current and potential clinical applications.
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