Baicalin, a metabolite of baicalein with antiviral activity against dengue virus.
Baicalin, a metabolite of baicalein with antiviral activity against dengue virus.
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DOI：
10.1038/srep05452
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发表时间：
2014-06-26
影响因子：
4.6
通讯作者：
Zandi K
中科院分区：
文献类型：
--
作者：
Moghaddam E;Teoh BT;Sam SS;Lani R;Hassandarvish P;Chik Z;Yueh A;Abubakar S;Zandi K
黄芩苷是黄芩中的黄酮类化合物，是黄芩素在不同动物模型和人体中释放的主要代谢产物。我们之前报道过黄芩素对登革病毒（DENV）的抗病毒活性。在此，我们检测了黄芩苷的体外抗DENV特性，并描述了黄芩苷在DENV-2（NGC株）复制的不同步骤中的抑制潜力。体外抗病毒实验表明，黄芩苷抑制病毒复制的IC_（50）为13.5 ± 0.08 μg/ml，SI为21.5。 黄芩苷对DENV-2细胞外颗粒具有杀病毒作用，IC 50为8.74 ± 0.08 μg/ml，抗吸附作用IC 50为18.07 ± 0.2 μg/ml。 结果表明，黄芩苷是黄芩素的主要代谢产物，具有体外抗DENV活性。对黄芩素和黄芩苷的抗病毒作用有待进一步研究。
Baicalin, a flavonoid derived from Scutellaria baicalensis, is the main metabolite of baicalein released following administration in different animal models and human. We previously reported the antiviral activity of baicalein against dengue virus (DENV). Here, we examined the anti-DENV properties of baicalin in vitro, and described the inhibitory potentials of baicalin at different steps of DENV-2 (NGC strain) replication. Our in vitro antiviral experiments showed that baicalin inhibited virus replication at IC50 = 13.5 ± 0.08 μg/ml with SI = 21.5 following virus internalization by Vero cells. Baicalin exhibited virucidal activity against DENV-2 extracellular particles at IC50 = 8.74 ± 0.08 μg/ml and showed anti-adsorption effect with IC50 = 18.07 ± 0.2 μg/ml. Our findings showed that baicalin as the main metabolite of baicalein exerting in vitro anti-DENV activity. Further investigations on baicalein and baicalin to deduce its antiviral therapeutic effects are warranted.
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