Alcohol Consumption in Healthy OPRM1 G Allele Carriers and Its Association with Impulsive Behavior.
Alcohol Consumption in Healthy OPRM1 G Allele Carriers and Its Association with Impulsive Behavior.
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健康 OPRM1 G 等位基因携带者的饮酒量及其与冲动行为的关系
DOI：
10.1093/alcalc/agv019
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发表时间：
2015
影响因子：
2.8
通讯作者：
Fehr C.
中科院分区：
文献类型：
--
作者：
Pfeifer P;Sariyar M;Eggermann T;Zerres K;Vernaleken I;Tüscher O;Fehr C.
酒精使用障碍（AUD）和冲动之间的联系已经建立。由于有证据表明AUD的遗传性，因此调查这两种疾病的潜在遗传倾向是一个重要问题。已经报道了AUD与μ-阿片受体1基因（OPRM 1）内编码单核苷酸多态性（SNP）（rs 1799971编码Asn 40 Asp氨基酸取代，A118 G）之间的关联。因此，我们测试了OPRM 1A 118 G多态性和饮酒以及冲动行为在social drinkers.MethodsA共214名健康男性社会饮酒者之间的关联。每个参与者的基因型为OPRM 1A 118 G变异。使用酒精使用障碍识别测试（AUDIT）项目评估酒精使用情况。冲动性使用UPPS冲动行为量表进行评估。统计分析采用SPSS V21软件进行相关分析、t检验和有序回归模型。结果214例受试者中49例为OPRM 1118 G等位基因携带者。平均而言，OPRM 1118 G携带者表现出略高的饮酒倾向。更高的饮酒频率之间的G等位基因携带者与更高的紧迫性和perseveration子impulsivity.ConclusionOur研究结果表明，遗传影响较高的饮酒倾向之间的社会饮酒携带118 G等位基因的theOPRM 1基因。OPRM 1118 G中紧迫感与较高饮酒频率之间的正相关性暗示了阿片系统在调节冲动性方面的功能意义。
AimsA link between alcohol use disorders (AUD) and impulsivity is well established. As there is evidence for the heritability of AUD, the investigation of the underlying genetic disposition for both conditions is an important issue. An association between AUD and a coding single nucleotide polymorphism (SNP) (rs1799971 encoding an Asn40Asp amino acid substitution, A118G) within the µ-opioid receptor 1 gene (OPRM1) has been reported. Therefore we tested the association between theOPRM1A118G polymorphism and drinking as well as impulsive behavior in social drinkers.MethodsA total of 214 healthy male social drinkers were recruited. Each participant was genotyped for theOPRM1A118G variant. Alcohol use was assessed with items of the Alcohol Use Disorders Identification Test (AUDIT). Impulsivity was assessed using the UPPS impulsive behavior scale. For statistical analyses, we considered correlations,t-tests and ordinal regression models using SPSS V21.ResultsIn total, 49 out of 214 participants were carriers of theOPRM1118G allele. On average theOPRM1118G carriers showed a slightly higher propensity for alcohol drinking. Higher drinking frequency among the G allele carriers was linked with higher urgency and perseveration subscores of impulsivity.ConclusionOur results suggest a genetically influenced higher propensity for alcohol drinking among social drinkers carrying the 118G allele of theOPRM1gene. The positive correlation between urgency and a higher drinking frequency among theOPRM1118G hint towards a functional meaning of the opioid system in the regulation of impulsivity.
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mu 和 delta 阿片受体在饮酒行为中的作用。
DOI：
10.2174/1874473710801020239
发表时间：
2008
期刊：
Current drug abuse reviews
影响因子：
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作者：
M. Méndez;M. Morales
通讯作者：
M. Morales
DOI：
10.1111/j.1530-0277.2011.01714.x
发表时间：
2012-07-01
影响因子：
3.2
作者：
Koller, Gabriele;Zill, Peter;Preuss, Ulrich W.
通讯作者：
Preuss, Ulrich W.
冲动是多巴胺受体 D2 基因与酒精依赖之间的中间环节
影响因子：
0.9
作者：
F. Limosin;J. Loze;C. Dubertret;L. Gouya;J. Adès;F. Rouillon;P. Gorwood
通讯作者：
P. Gorwood
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影响因子：
0.8
作者：
R. E. Schmidt;Mathijs D'Acremont;M. Linden
通讯作者：
M. Linden
影响因子：
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作者：
Anton, Raymond F.;Oroszi, Gabor;Goldman, David
通讯作者：
Goldman, David