Progress in the development of a corneal replacement: keratoprostheses and tissue-engineered corneas
Progress in the development of a corneal replacement: keratoprostheses and tissue-engineered corneas
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角膜替代物的开发进展：人工角膜和组织工程角膜
DOI：
10.1586/17434440.3.1.59
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发表时间：
2006
影响因子：
3.1
通讯作者：
H. Sheardown
中科院分区：
文献类型：
--
作者：
Derek Duan;B. Klenkler;H. Sheardown
在过去的5年里，角膜替代物的发展取得了快速的进展。传统上，随着全球对替代组织的需求日益增加，它们被分为两类，角膜假体和组织工程化角膜等价物。目前世界上有几种不同的角膜假体模型在临床上使用。最受欢迎和最广泛宣传的是AlphaCor™模型，该模型在临床上取得了重大成功。然而，仍然需要改进，目前大多数研究的目的是在更基本的水平上更好地了解合成材料与周围生物之间的相互作用。这种更好的理解无疑将导致在不久的将来改进现有模型和开发新模型。虽然组织工程化角膜替代物的研究时间要短得多，但越来越多的证据表明，主要由天然材料组成的组织工程化角膜替代物将在不远的将来出现。研究小组在体外和体内都报告了强劲的结果。胶原基质的强度及其支持细胞渗透的能力一直是研究的主要途径。各种胶原蛋白交联技术已经被使用。已观察到角膜的三个主要细胞的渗透。最重要的是，这些材料支持神经向内生长的能力已经被证明。虽然这两种类型的角膜置换仍然存在挑战，但最近取得的相当大的进展表明，用于治疗各种角膜疾病的可靠植入物将是可用的。这篇综述将提供最新结果的概述，并将为角膜置换研究的未来提供洞察力。
Rapid progress has been made in the past 5 years in the development of corneal replacements. Traditionally they are divided into two categories, keratoprostheses and tissue-engineered corneal equivalents, as replacement tissues are increaseingly in demand worldwide. There are currently several different keratoprosthesis models in clinical use around the world. The most popular and most widely publicized is the AlphaCor™ model, which has enjoyed significant clinical success. However, improvements remain to be made, and the aim of most of the current research is to better understand the interactions between a synthetic material and the surrounding biology on a more fundamental level. This improved understanding will no doubt lead to improvements in current models and to the development of new models in the near future. While tissue-engineered corneal equivalents have been under investigation for considerably less time, there is growing evidence to suggest that a tissue-engineered corneal equivalent comprised of primarily natural materials will exist in the not too distant future. Research groups have reported strong in vitro and in vivo results. The strength of the collagen matrix and its ability to support cell infiltration have been the primary avenues of research. Various collagen crosslinking techniques have been used. Infiltration of three major cells of the cornea has been observed. Most importantly, the ability of these materials to support nerve ingrowth has been demonstrated. While challenges remain with both types of corneal replacements, the considerable progress in the recent past suggests that reliable implants for the treatment of a variety of corneal diseases will be available. This review will provide an overview of recent results, and will provide insight into the future of research on corneal replacements.
角膜上皮细胞在束缚蛋白/肽表面修饰的水凝胶上生长。
DOI：
10.1002/jbm.b.30131
发表时间：
2005
期刊：
Journal of biomedical materials research. Part B, Applied biomaterials
影响因子：
--
作者：
Jacob,JeanT;Rochefort,JamesR;Bi,Jingjing;Gebhardt,BryanM
通讯作者：
Gebhardt,BryanM
合成角膜材料上角膜上皮细胞生长的比较。
影响因子：
14
作者：
George,Andrew;Pitt,WilliamG
通讯作者：
Pitt,WilliamG