Consanguinity and increased risk for schizophrenia in Egypt.
Consanguinity and increased risk for schizophrenia in Egypt.
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DOI：
10.1016/j.schres.2010.03.026
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发表时间：
2010-07
影响因子：
4.5
通讯作者：
Nimgaonkar, Vishwajit L.
中科院分区：
文献类型：
--
作者：
Mansour, Hader;Fathi, Warda;Klei, Lambertus;Wood, Joel;Chowdari, Kodavali;Watson, Annie;Eissa, Ahmed;Elassy, Mai;Ali, Ibtihal;Salah, Hala;Yassin, Amal;Tobar, Salwa;El-Boraie, Hala;Gaafar, Hanan;Ibrahim, Nahed E.;Kandil, Kareem;El-Bahaei, Wafaa;El-Boraie, Osama;Alatrouny, Mohamed;El-Chennawi, Farha;Devlin, Bernie;Nimgaonkar, Vishwajit L.
在一些中东国家，血缘关系被认为是精神病的一个危险因素，但缺乏足够的控制数据。我们最近在埃及的研究表明，与对照组相比，双相I型情感障碍（BP1）患者的亲本血缘率升高。我们现在已经将我们的分析扩展到同一人群中的精神分裂症（SZ）。在埃及曼苏拉曼苏拉大学医院进行了一项病例对照研究（SZ, n = 75；对照组，n = 126，及其可用父母）。根据家族史数据（“自我报告”）估计亲属关系的患病率，然后使用短串联重复多态性（STRPs, n = 63）进行DNA分析（“基于DNA的”比率）。自我报告的亲缘关系在患者中显著升高（SZ: 46.6%，对照组：19.8%,OR 3.53, 95% CI 1.88, 6.64; p = 0.000058, 1 d f）。这些差异通过基于DNA的近交系数估计值得到证实（近交系数为平均值±标准误差，病例为0.058±0.007，对照组为0.022±0.003）。在尼罗河三角洲地区的埃及SZ患者中，血亲率显著升高。这种关联与我们在早期研究中观察到的BP1相似。如果重复，与血缘关系相关的重大风险会引起公众健康担忧。它们也可能为基因定位研究铺平道路。
Consanguinity has been suggested as a risk factor for psychsoses in some Middle Eastern countries, but adequate control data are unavailable. Our recent studies in Egypt have shown elevated parental consanguinity rates among patients with bipolar I disorder (BP1), compared with controls. We have now extended our analyses to Schizophrenia (SZ) in the same population. A case-control study was conducted at Mansoura University Hospital, Mansoura, Egypt (SZ, n = 75; controls, n = 126, and their available parents). The prevalence of consanguinity was estimated from family history data (‘self report’), followed by DNA analysis using short tandem repeat polymorphisms (STRPs, n = 63) (‘DNA-based’ rates). Self reported consanguinity was significantly elevated among the patients (SZ: 46.6%, controls: 19.8%, OR 3.53, 95% CI 1.88, 6.64; p = 0.000058, 1 d.f.). These differences were confirmed using DNA based estimates for coefficients of inbreeding (inbreeding coefficients as means ± standard error, cases: 0.058 ± 0.007, controls: 0.022 ± 0.003). Consanguinity rates are signifcantly elevated among Egyptian SZ patients in the Nile delta region. The associations are similar to those observed with BP1 in our earlier study. If replicated, the substantial risk associated with consanguinity raises public health concerns. They may also pave the way for gene mapping studies.
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DOI：
10.1002/ajmg.c.20003
发表时间：
2003-08-15
影响因子：
3.1
作者：
Puffenberger, EG
通讯作者：
Puffenberger, EG
影响因子：
1.5
作者：
Hussain, R
通讯作者：
Hussain, R
DOI：
10.1002/ajmg.b.30913
发表时间：
2009-09-05
影响因子：
2.8
作者：
Mansour, Hader;Klei, Lambertus;Nimgaonkar, Vishwajit L.
通讯作者：
Nimgaonkar, Vishwajit L.
影响因子：
4
作者：
Hoodfar, E;Teebi, AS
通讯作者：
Teebi, AS
DOI：
10.1073/pnas.93.12.6140
发表时间：
1996-06-11
影响因子：
11.1
作者：
Charlesworth, B;Hughes, KA
通讯作者：
Hughes, KA