Clinical feasibility and validation of 3D principal strain analysis from cine MRI: comparison to 2D strain by MRI and 3D speckle tracking echocardiography.
Clinical feasibility and validation of 3D principal strain analysis from cine MRI: comparison to 2D strain by MRI and 3D speckle tracking echocardiography.
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DOI：
10.1007/s10554-017-1199-7
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发表时间：
2017-12
期刊：
影响因子：
--
通讯作者：
White JA
中科院分区：
文献类型：
--
作者：
Satriano A;Heydari B;Narous M;Exner DV;Mikami Y;Attwood MM;Tyberg JV;Lydell CP;Howarth AG;Fine NM;White JA
二维 (2D) 应变分析受到几何形状相关的变形参考方向（即径向、周向和纵向）的约束，并遵循圆柱形腔室结构的假设。三维 (3D) 主应变分析可以通过参考变形的固有（即主）方向来克服此类限制。本研究旨在证明常规 2D 电影 MRI 的 3D 主应变分析的临床可行性，并对 2D 标记电影分析和 3D 斑点跟踪超声心动图的应变进行验证。对 31 名接受心脏 MRI 的患者进行了研究。使用定制软件从常规多平面 2D 电影 SSFP 图像中测量 3D 应变，该软件旨在将 4D 变形场应用于 3D 心脏模型以获得主应变。对应变估计值与 2D 标记电影、2D 非标记电影（特征跟踪）和 3D 斑点跟踪超声心动图 (STE) 的估计值进行了比较。平均年龄为 51±14 岁（36% 为女性）。平均左心室射血分数为 66±10%（范围 37-80%）。 3D 主应变分析在所有受试者中都是可行的，并且显示出观察者间和观察者内的高再现性（ICC 范围分别为 0.83-0.97 和 0.83-0.98，所有方向的 p < 0.001）。分别观察到最小和最大主应变与以下各项的强相关性：纵向应变（r = 0.81 和 r = −0.64）、周向应变（r = 0.76 和 r = −0.58）和径向应变（r = −0.80 和 r = 0.63）的 3D STE 估计值（所有p < 0.001）；纵向（r = 0.81 和 r = −0.81）、周向（r = 0.87 和 r = −0.85）和径向（r = −0.76 和 r = 0.81）应变的二维标记电影估计（p < 0.0001全部）；纵向（r = 0.85 和 -0.83）、周向（r = 0.88 和 r = −0.87）和径向应变（r = −0.79 和 r = 0.84，p < 0.0001）的二维电影（特征跟踪）估计。使用常规多平面 2D 电影 MRI 进行 3D 主应变分析是可行的，并且显示出高再现性，与 2D 常规应变分析和基于 3D STE 的分析具有很强的相关性。鉴于其独立于与几何相关的变形方向，该技术可能为心肌疾病的检测和预测提供独特的益处，并且值得扩大研究。本文的在线版本 (doi:10.1007/s10554-017-1199-7) 包含补充材料，可供授权用户使用。
Two-dimensional (2D) strain analysis is constrained by geometry-dependent reference directions of deformation (i.e. radial, circumferential, and longitudinal) following the assumption of cylindrical chamber architecture. Three-dimensional (3D) principal strain analysis may overcome such limitations by referencing intrinsic (i.e. principal) directions of deformation. This study aimed to demonstrate clinical feasibility of 3D principal strain analysis from routine 2D cine MRI with validation to strain from 2D tagged cine analysis and 3D speckle tracking echocardiography. Thirty-one patients undergoing cardiac MRI were studied. 3D strain was measured from routine, multi-planar 2D cine SSFP images using custom software designed to apply 4D deformation fields to 3D cardiac models to derive principal strain. Comparisons of strain estimates versus those by 2D tagged cine, 2D non-tagged cine (feature tracking), and 3D speckle tracking echocardiography (STE) were performed. Mean age was 51 ± 14 (36% female). Mean LV ejection fraction was 66 ± 10% (range 37–80%). 3D principal strain analysis was feasible in all subjects and showed high inter- and intra-observer reproducibility (ICC range 0.83–0.97 and 0.83–0.98, respectively—p < 0.001 for all directions). Strong correlations of minimum and maximum principal strain were respectively observed versus the following: 3D STE estimates of longitudinal (r = 0.81 and r = −0.64), circumferential (r = 0.76 and r = −0.58) and radial (r = −0.80 and r = 0.63) strain (p < 0.001 for all); 2D tagged cine estimates of longitudinal (r = 0.81 and r = −0.81), circumferential (r = 0.87 and r = −0.85), and radial (r = −0.76 and r = 0.81) strain (p < 0.0001 for all); and 2D cine (feature tracking) estimates of longitudinal (r = 0.85 and −0.83), circumferential (r = 0.88 and r = −0.87), and radial strain (r = −0.79 and r = 0.84, p < 0.0001 for all). 3D principal strain analysis is feasible using routine, multi-planar 2D cine MRI and shows high reproducibility with strong correlations to 2D conventional strain analysis and 3D STE-based analysis. Given its independence from geometry-related directions of deformation this technique may offer unique benefit for the detection and prognostication of myocardial disease, and warrants expanded investigation. The online version of this article (doi:10.1007/s10554-017-1199-7) contains supplementary material, which is available to authorized users.
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6.2
作者：
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