Chromosome Tug of War: Dicentric Chromosomes and the Centromere Strength Hypothesis.

Chromosome Tug of War: Dicentric Chromosomes and the Centromere Strength Hypothesis.
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DOI:
10.3390/cells11223550
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发表时间:
2022-11-10
期刊:
影响因子:
6
通讯作者:
Golic, Kent G.
Golic, Kent G.
中科院分区:
生物学2区
文献类型:
--
作者:
Hill, Hunter J.;Golic, Kent G.

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根据双着丝粒染色体的行为,提出了着丝粒强度变化的概念,至今已有70年的历史。从这些早期实验中得出的一个关键结论是,一些着丝粒可以用足够的力量拉断双着丝粒染色体桥,而另一些则不能。在随后的几十年里,有许多研究来表征所涉及的各种成分的强度,如纺锤体,动粒和染色体本身。我们回顾这些不同的测量,以确定是否着丝粒强度的结论是支持目前的证据,特别注意描述的果蝇动粒的原始结论的基础上。
It has been 70 years since the concept of varied centromere strengths was introduced based on the behavior of dicentric chromosomes. One of the key conclusions from those early experiments was that some centromeres could pull with sufficient force to break a dicentric chromosome bridge, while others could not. In the ensuing decades there have been numerous studies to characterize strengths of the various components involved, such as the spindle, the kinetochore, and the chromosome itself. We review these various measurements to determine if the conclusions about centromere strength are supported by current evidence, with special attention to characterization of Drosophila melanogaster kinetochores upon which the original conclusions were based.
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