Brain Tumor Typing and Therapy Using Combined Ex Vivo Magnetic Resonance Spectroscopy and Molecular Genomics
Brain Tumor Typing and Therapy Using Combined Ex Vivo Magnetic Resonance Spectroscopy and Molecular Genomics
复制标题
结合体外磁共振波谱和分子基因组学进行脑肿瘤分型和治疗
DOI：
10.1007/978-94-007-7217-5_13
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
A. Tzika
中科院分区：
文献类型：
--
作者：
L. Astrakas;A. Tzika
A novel approach was developed that combines biomarkers detected with magnetic resonance spectroscopy (MRS) and molecular genomics to improve the typing and prognostication of biospecimens in clinical medicine. Metabolite and genome wide profiles from 55 biopsies from subjects with brain tumors were analyzed with a classification algorithm that produces unique tumor fingerprints. We found that the fusion of 15 gene expressions and 15 MRS metabolites were able to distinguish tumor categories and predict survival better than when either dataset was used alone. Our approach improves the typing and understanding of the complexity of human brain tumors, generates testable hypotheses regarding neoplasia and promises to guide human brain tumor therapy. Our results further elucidate the biology of brain malignancy subtypes in brain tumor patients, and increase the overall potential for success of future studies that combine clinical MRI, MRS and MR imaging of gene expression in vivo.
登录
查看更多内容
影响因子：
2.3
作者：
Horská A;Barker PB
通讯作者：
Barker PB
影响因子：
15.9
作者：
Cheng, LL;Anthony, DC;Gonzalez, RG
通讯作者：
Gonzalez, RG
影响因子：
5.2
作者：
Andronesi OC;Blekas KD;Mintzopoulos D;Astrakas L;Black PM;Tzika AA
通讯作者：
Tzika AA
影响因子：
4
作者：
Glunde K;Bhujwalla ZM
通讯作者：
Bhujwalla ZM