Changes in resting functional connectivity during abstinence in stimulant use disorder: a preliminary comparison of relapsers and abstainers.
Changes in resting functional connectivity during abstinence in stimulant use disorder: a preliminary comparison of relapsers and abstainers.
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DOI：
10.1016/j.drugalcdep.2014.03.024
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发表时间：
2014-06-01
影响因子：
4.2
通讯作者：
Lim, Kelvin O.
中科院分区：
文献类型：
--
作者：
Camchong, Jazmin;MacDonald, Angus W., III;Mueller, Bryon A.;Nelson, Brent;Specker, Sheila;Slaymaker, Valerie;Lim, Kelvin O.
先前确定的休息功能连接（FC）的差异，在个人与兴奋剂使用障碍（SUD）表明，在神经区域的不平衡，介导的行为方面相关的成瘾，如情绪调节和奖励处理。有必要进一步调查复发者和未复发者之间的这些差异。这是第一个纵向研究最近禁欲SUD（SUD-RA），确定特定的FC变化，随后复发（与禁欲）。我们假设（1）随后的复发者（与戒酒者相比）将显示情绪调节区域的FC较低，奖励处理区域的FC较高;（2）FC差异随着时间的推移会更加明显。我们检查了18名SUD-RA（8名女性，年龄：M = 22.05 ± 2.64）和15名非物质滥用对照（NSAC; 5名女性，年龄：M = 24.21 ± 5.76）在时间1（禁欲约5周）时的静息FC。在时间2（禁欲约13周）重新检查了14例NSAC和12例SUD-RA。通过基于种子的FC测量，我们检查了在随后6个月内戒断或复发的SUD-RA之间的FC差异。复发者（与戒断者相比）在时间1时（1）丘脑核（NAcc）和左额极皮质（FPC），（2）NAcc和后扣带回，（3）膝下前扣带回和左FPC之间的FC较高。随着时间的推移，复发者（与戒烟者相比）在这些区域内表现出更大的FC强度降低。戒烟5 - 13周的复吸者（与戒断者相比）的静息FC减少可能是复吸脆弱性的生物标志物。这些初步发现需要用更大的样本量进行复制。
Previously identified resting functional connectivity (FC) differences in individuals with stimulant use disorder (SUD) suggest an imbalance in neural regions that mediate behavioral aspects relevant to addiction such as emotion regulation and reward processing. There is a need to further investigate these differences across time between those that relapse and those that do not. This is the first longitudinal study of recently abstinent SUD (SUD-RA) that identifies specific FC changes in subsequent relapsers (vs abstainers). We hypothesized that (1) subsequent relapsers (vs abstainers) will show lower FC of emotion regulation regions and higher FC of reward processing regions and (2) FC differences would be more evident across time. We examined resting FC in 18 SUD-RAs (8 females, age: M=22.05±2.64) and 15 non-substance abusing controls (NSAC; 5 females, age: M=24.21±5.76) at Time 1 (abstinent ~5 weeks). Fourteen NSAC and 12 SUD-RAs were re-examined at Time 2 (abstinent ~13 weeks). With seed-based FC measures, we examined FC differences between SUD-RAs that abstained or relapsed over the subsequent 6 months. Relapsers (vs abstainers) had higher FC between (1) nucleus accumbens (NAcc) and left frontopolar cortex (FPC), (2) NAcc and posterior cingulate gyrus and (3) subgenual anterior cingulate and left FPC at Time 1. Relapsers (vs abstainers) showed larger reduction in FC strength within these regions across time. Resting FC reduction found in relapsers (vs. abstainers) from five to thirteen weeks of abstinence may be a biological marker of relapse vulnerability. These preliminary findings require replication with larger sample sizes.
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影响因子：
19.9
作者：
Etkin, Amit;Egner, Tobias;Kalisch, Raffael
通讯作者：
Kalisch, Raffael
影响因子：
4.8
作者：
Clark, Vincent P.;Beatty, Gregory K.;Anderson, Robert E.;Kodituwakku, Piyadassa;Phillips, John P.;Lane, Terran D. R.;Kiehl, Kent A.;Calhoun, Vince D.
通讯作者：
Calhoun, Vince D.
DOI：
10.1073/pnas.0601417103
发表时间：
2006-09-12
影响因子：
11.1
作者：
Damoiseaux, J. S.;Rombouts, S. A. R. B.;Beckmann, C. F.
通讯作者：
Beckmann, C. F.
影响因子：
10.6
作者：
Kelly, Clare;Zuo, Xi-Nian;Gotimer, Kristin;Cox, Christine L.;Lynch, Lauren;Brock, Dylan;Imperati, Davide;Garavan, Hugh;Rotrosen, John;Castellanos, F. Xavier;Milham, Michael P.
通讯作者：
Milham, Michael P.
影响因子：
3.7
作者：
Bode S;He AH;Soon CS;Trampel R;Turner R;Haynes JD
通讯作者：
Haynes JD