Reduced interhemispheric resting state functional connectivity in cocaine addiction.
Reduced interhemispheric resting state functional connectivity in cocaine addiction.
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DOI：
10.1016/j.biopsych.2010.11.022
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发表时间：
2011-04-01
影响因子：
10.6
通讯作者：
Milham, Michael P.
中科院分区：
文献类型：
--
作者：
Kelly, Clare;Zuo, Xi-Nian;Gotimer, Kristin;Cox, Christine L.;Lynch, Lauren;Brock, Dylan;Imperati, Davide;Garavan, Hugh;Rotrosen, John;Castellanos, F. Xavier;Milham, Michael P.
可卡因成瘾的模型强调了支持认知控制过程的额叶神经回路紊乱的作用。然而，在大脑区域之间，特别是大脑半球之间，与成瘾相关的功能相互作用的改变很少被直接检查。静息状态功能磁共振成像方法揭示了功能磁共振成像信号中连贯的自发波动模式，提供了一种直接量化半球之间功能相互作用的方法。我们使用一种最近被证实的名为“体素镜像同位连通性”的方法来检查可卡因依赖的半球间静息状态功能连通性（RSFC）。我们比较了25名在过去12个月内符合DSM-IV可卡因依赖标准的成年人（年龄35.0±8.8），但目前正在戒可卡因（bbbb2周），以及24名年龄、性别、教育程度和就业状况匹配的健康对照组（35.1±7.5）的半球间RSFC。我们观察到可卡因依赖参与者的前额叶半球间RSFC相对于对照组减少。进一步的分析表明，在背侧注意网络（DAN）节点（包括双侧外侧额叶区、内侧运动前区和后顶叶区）中，与可卡因依赖相关的半球间RSFC显著减少。此外，在可卡因依赖组中，DAN内的RSFC与自我报告的注意力缺失有关。我们的发现提供了进一步的证据，证明长期暴露于可卡因与支持认知控制的大规模脑回路中断之间存在关联。我们没有检测到DTI测量的组间差异，这表明在没有检测到支持该结构的白质微观结构异常的情况下，可以观察到与可卡因暴露相关的大脑功能结构的改变。
Models of cocaine addiction emphasize the role of disrupted frontal circuitry supporting cognitive control processes. Yet, addiction-related alterations in functional interactions among brain regions, especially between the cerebral hemispheres, are rarely examined directly. Resting state fMRI approaches, which reveal patterns of coherent spontaneous fluctuations in the fMRI signal, offer a means to directly quantify functional interactions between the hemispheres. We examined interhemispheric resting state functional connectivity (RSFC) in cocaine dependence using a recently validated approach named “voxel-mirrored homotopic connectivity.” We compared interhemispheric RSFC between 25 adults (aged 35.0±8.8) meeting DSM-IV criteria for cocaine dependence within the past 12 months, but currently abstaining (>2 weeks) from cocaine, and 24 healthy comparisons (35.1±7.5), group-matched on age, sex, education and employment status. We observed reduced prefrontal interhemispheric RSFC in cocaine dependent participants relative to controls. Further analyses demonstrated a striking cocaine-dependence-related reduction in interhemispheric RSFC among nodes of the dorsal attention network (DAN), comprising bilateral lateral frontal, medial premotor and posterior parietal areas. Further, within the cocaine-dependent group, RSFC within the DAN was associated with self-reported lapses of attention. Our findings provide further evidence of an association between chronic exposure to cocaine and disruptions within large-scale brain circuitry supporting cognitive control. We did not detect group differences in DTI measures, suggesting that alterations in the brain’s functional architecture associated with cocaine exposure can be observed in the absence of detectable abnormalities in the white matter microstructure supporting that architecture.
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影响因子：
25
作者：
Asplund, Christopher L.;Todd, J. Jay;Snyder, Andy P.;Marois, Rene
通讯作者：
Marois, Rene
影响因子：
10.6
作者：
Franklin, TR;Acton, PD;Childress, AR
通讯作者：
Childress, AR
影响因子：
3.1
作者：
BROADBENT, DE;COOPER, PF;PARKES, KR
通讯作者：
PARKES, KR
探索人类大脑功能的科学
DOI：
10.1073/pnas.0911855107
发表时间：
2010-03-09
影响因子：
11.1
作者：
Biswal, Bharat B.;Mennes, Maarten;Milham, Michael P.
通讯作者：
Milham, Michael P.
影响因子：
5.7
作者：
Cole, David M.;Beckmann, Christian F.;Beaver, John D.
通讯作者：
Beaver, John D.