Knowledge graphs of ethical concerns of cerebral organoids.
Knowledge graphs of ethical concerns of cerebral organoids.
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DOI：
10.1111/cpr.13239
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发表时间：
2022-08
影响因子：
8.5
通讯作者：
中科院分区：
文献类型：
--
作者：
脑类器官技术的快速发展和脑类器官的逐渐成熟，凸显了对相关伦理问题进行前瞻性研究的必要性。利用知识图谱和CiteSpace软件进行统计分析，从文献计量学的角度对脑类器官伦理问题的研究现状进行全面分析。通过对脑类器官伦理学发表论文、关键词共现图、文献共被引图和知识聚类图的统计分析，探讨了脑类器官伦理学研究的现状、技术发展与伦理研究的内在关系以及学术界关注的伦理问题。最后，利用关键词时区图和相关统计数据对未来脑类器官伦理学研究的趋势和热门话题进行了分析和预测。我们证明，尽管脑类器官的伦理问题早已被讨论，但直到2017年，当脑类器官逐渐更紧密地模仿人类大脑，并越来越多地与嵌合体研究相结合时，伦理问题才开始受到更多关注。最近的关键伦理问题主要分为三类：生命科学中常见的问题，特定于大脑类器官的问题，以及交叉领域的问题。这些日益增加的伦理问题与技术的不断发展有着内在的联系。分析指出，未来的研究应关注脑类器官特有的意识伦理问题、跨领域的伦理问题以及立法和监管体系的建设和完善。虽然脑类器官的研究可以造福生物医学领域，但相关的伦理问题也越来越受到重视，这与技术的不断发展有着内在的联系。未来关于脑类器官研究的伦理研究应关注意识的伦理问题、跨领域的伦理问题以及监管体系的完善。通过对脑类器官伦理学发表论文、关键词共现图、文献共被引图和知识聚类图的统计分析，考察了脑类器官伦理学研究的现状。我们还使用关键词时区图和相关统计数据分析和预测未来脑类器官伦理学研究的趋势和热门话题。
The rapid development of cerebral organoid technology and the gradual maturity of cerebral organoids highlight the necessity of foresighted research on relevant ethical concerns. We employed knowledge graphs and conducted statistical analysis with CiteSpace for a comprehensive analysis of the status quo of the research on the ethical concerns of cerebral organoids from a bibliometric perspective. We performed a statistical analysis of published papers on cerebral organoid ethics, keyword co‐occurrence graph, literature co‐citation and knowledge clustering graph to examine the status of the ethics research, internal relationship between technological development and ethical research, and ethical concerns of the academia. Finally, we used a keyword time zone graph and related statistics to analyze and predict the trends and popular topics of future cerebral organoids ethics research. We demonstrated that although the ethical concerns of cerebral organoids have long been discussed, it was not until 2017 that the ethical issues began to receive more attention, when cerebral organoids were gradually mimicking the human brain more closely and increasingly being combined with chimera research. The recent key ethical concerns are primarily divided into three categories: concerns that are common in life sciences, specific to cerebral organoids, and present in cross‐fields. These increasing ethical concerns are inherently related to the continual development of technology. The analysis pointed out that future research should focus on the ethical concerns of consciousness that are unique to cerebral organoids, ethical concerns of cross‐fields, and construction and improvement of legislative and regulatory systems. Although research on cerebral organoids can benefit the biomedicine field, the relevant ethical concerns are significant and have received increasing attention, which are inherently related to the continual development of technology. Future studies in ethics regarding cerebral organoid research should focus on the ethical concerns of consciousness, and cross‐fields, as well as the improvement of regulatory systems. We performed a statistical analysis of published papers on cerebral organoid ethics, keyword co‐occurrence graph, literature co‐citation and knowledge clustering graph to examine the status of the ethics research. We also used a keyword time zone graph and related statistics to analyse and predict the trends and popular topics of future cerebral organoids ethics research.
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DOI：
10.3390/medicina57060532
发表时间：
2021-05-27
期刊：
Medicina (Kaunas, Lithuania)
影响因子：
--
作者：
Ide K;Matsuoka N;Fujita M
通讯作者：
Fujita M
影响因子：
11
作者：
Gonzalez C;Armijo E;Bravo-Alegria J;Becerra-Calixto A;Mays CE;Soto C
通讯作者：
Soto C
影响因子：
2.1
作者：
Koplin, Julian J.;Savulescu, Julian
通讯作者：
Savulescu, Julian
影响因子：
64.8
作者：
Farahany NA;Greely HT;Hyman S;Koch C;Grady C;Pașca SP;Sestan N;Arlotta P;Bernat JL;Ting J;Lunshof JE;Iyer EPR;Hyun I;Capestany BH;Church GM;Huang H;Song H
通讯作者：
Song H
影响因子：
12.6
作者：
Bi FC;Yang XH;Cheng XY;Deng WB;Guo XL;Yang H;Wang Y;Li J;Yao Y
通讯作者：
Yao Y