Augmentation of postswelling surgical sealant potential of adhesive hydrogels.
Augmentation of postswelling surgical sealant potential of adhesive hydrogels.
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DOI：
10.1002/jbm.a.32942
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发表时间：
2010-12-15
影响因子：
4.9
通讯作者：
Edelman, Elazer R.
中科院分区：
文献类型：
--
作者：
Shazly, Tarek M.;Baker, Aaron B.;Naber, John R.;Bon, Adriana;Van Vliet, Krystyn J.;Edelman, Elazer R.
由星形聚乙二醇胺和线性葡聚糖醛聚合物（PEG：葡聚糖）形成的双组分水凝胶显示出作为组织特异性手术密封剂的前景。然而，PEG:葡聚糖溶胀后，软组织的粘附强度会显着降低，这可能会限制材料固定分离组织并防止手术部位渗漏的能力。我们将修饰的氨基酸 l-3,4-二羟基苯丙氨酸 (l-DOPA) 共价结合到 PEG: 葡聚糖中，以增强膨胀后密封剂的性能。 l-DOPA 是海洋动物粘合斑块的重要成分，已用于赋予合成材料湿粘合力。由于 PEG: 葡聚糖内聚力和粘附力都是由醛-胺相互作用介导的，因此 L-DOPA 侧基使其成为一种有效的网络调节剂，有可能影响多种材料特性。在水介质中浸泡一小时后，与纯水凝胶相比，掺杂有 3 mM l-DOPA/M 醛的 PEG: 葡聚糖平均溶胀减少 50.3%，刚度增加 287.4%，功能粘合强度增加 53.6%。将 l-DOPA 浓度增加至 11 mM l-DOPA/M 醛同样可以减少膨胀并减轻水合引起的性能损失，但会牺牲初始功能粘合强度、材料模量和生物相容性。总而言之，这些数据支持定制的左旋多巴缀合作为增强 PEG: 葡聚糖密封剂临床性能的有前途的方法。
Two-component hydrogels formed with star polyethylene glycol amine and linear dextran aldehyde polymers (PEG:dextran) show promise as tissue-specific surgical sealants. There is however a significant loss of adhesion strength to soft tissues following PEG:dextran swelling, which may limit material ability to appose disjoined tissues and prevent leakage from surgical sites. We covalently incorporated the modified amino acid l-3,4-dihydroxyphenylalanine (l-DOPA) into PEG:dextran to enhance post-swelling sealant performance. l-DOPA is an essential component of marine animal adhesive plaques and has been used to confer wet adhesion in synthetic materials. As both PEG:dextran cohesion and adhesion are mediated by aldehyde-amine interactions, l-DOPA side-groups make it a potent network modulator with potential to affect multiple material properties. Following one hour submersion in aqueous media, PEG:dextran doped with 3 mM l-DOPA/M aldehyde on average swelled 50.3% less, had 287.4% greater stiffness and had 53.6% greater functional adhesion strength compared to the neat hydrogel. Increased concentrations of l-DOPA up to 11 mM l-DOPA/M aldehyde similarly curtailed swelling and mitigated property loss with hydration, but sacrificed initial functional adhesion strength, material modulus and biocompatibility. Taken together, these data support tailored l-DOPA conjugation as a promising approach to enhance the clinical performance of PEG:dextran sealants.
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DOI：
10.1163/156856208786140337
发表时间：
2008-01-01
影响因子：
3.6
作者：
Samuel, Newton T.;Vailhe, Elizabeth;Maziarz, Peter E.
通讯作者：
Maziarz, Peter E.
影响因子：
2.1
作者：
Shima, Ichirou;Katsuda, Shogo;Sasaki, Hiroshi
通讯作者：
Sasaki, Hiroshi
影响因子：
4.6
作者：
Artzi N;Shazly T;Crespo C;Ramos AB;Chenault HK;Edelman ER
通讯作者：
Edelman ER
影响因子：
20.1
作者：
Baker AB;Groothuis A;Jonas M;Ettenson DS;Shazly T;Zcharia E;Vlodavsky I;Seifert P;Edelman ER
通讯作者：
Edelman ER
影响因子：
4
作者：
Burke, Sean A.;Ritter-Jones, Marsha;Messersmith, Phillip B.
通讯作者：
Messersmith, Phillip B.