Host genetic factors affecting spontaneous HBsAg seroclearance in chronic hepatitis B patients.
Host genetic factors affecting spontaneous HBsAg seroclearance in chronic hepatitis B patients.
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DOI：
10.1371/journal.pone.0053008
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Kao JH
中科院分区：
文献类型：
--
作者：
Cheng HR;Liu CJ;Tseng TC;Su TH;Yang HI;Chen CJ;Kao JH
慢性乙型肝炎(CHB)患者的乙肝表面抗原(HBs)自发清除通常预示着肝炎活动的缓解和良好的预后。人类白细胞抗原DPA1区附近的rs3077和人类白细胞抗原DPB1区附近的rs9277535这两个单核苷酸多态(SNP)已被证明与急性乙肝病毒感染后的病毒持久性有关。然而，这两个SNP对慢性乙型病毒性肝炎患者的乙肝表面抗原自发清除的影响却知之甚少。本病例对照研究包括100例HBeAg阴性的慢性乙肝病毒携带者(病例组)和100例年龄匹配的HBeAg阴性的慢性乙肝病毒携带者(对照组)。我们研究了这两个SNP与乙肝表面抗原清除的关系。病例组中rs9277535非GG基因频率较高(57%比42%)。携带rs9277535非GG基因的患者清除乙肝表面抗原的几率较高[优势比(OR)：1.83，95%可信区间(CI)：1.04∼3.21，P = 0.034]。与rs3077和rs9277535的GG单倍型相比，GA单倍型发生自发性乙肝表面抗原丢失的几率更高(OR：2.17，95%CI：1.14∼4.16，P = 0.030)。结论：在慢性乙型肝炎患者中，rs9277535非GG基因与自发性乙肝表面抗原血清清除的可能性较高相关。
Spontaneous clearance of hepatitis B surface antigen (HBsAg) in chronic hepatitis B (CHB) patients usually indicates a remission of hepatitis activity and a favorable outcome. Two single nucleotide polymorphisms (SNP), rs3077 near HLA-DPA1 region and rs9277535 near HLA-DPB1 region, have been shown to be associated with HBV persistence after acute HBV infection. However, little is known about the impact of these 2 SNPs on spontaneous HBsAg clearance in CHB patients. In this case-control study, a total of 100 male HBeAg-negative chronic HBV carriers who cleared HBsAg spontaneously (case group) and 100 age-matched HBeAg-negative male patients with persistent HBsAg positivity (control group) were enrolled. We investigated the relationship between these 2 SNPs and HBsAg clearance. There was a higher frequency of rs9277535 non-GG genotype in the case group (57% vs. 42%). Patients with rs9277535 non-GG genotype had a higher chance to clear HBsAg [Odds ratio (OR): 1.83, 95% confidence interval (CI): 1.04∼3.21, P = 0.034]. Compared to GG haplotype of rs3077 and rs9277535, GA haplotype had a higher chance of achieving spontaneous HBsAg loss (OR: 2.17, 95% CI: 1.14∼4.16, P = 0.030). In conclusion, rs9277535 non-GG genotype is associated with a higher likelihood of spontaneous HBsAg seroclearance in CHB patients.
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影响因子：
20.3
作者：
Nagalla, Srikanth;Shaw, Chad;Bray, Paul F.
通讯作者：
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影响因子：
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--
DOI：
10.1073/pnas.091062498
发表时间：
2001-04-24
影响因子：
11.1
作者：
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通讯作者：
Chu, G
影响因子：
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作者：
Lawrie, Charles H.;Gal, Shira;Harris, Adrian L.
通讯作者：
Harris, Adrian L.
影响因子：
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作者：
Duttagupta R;Jiang R;Gollub J;Getts RC;Jones KW
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