TAS2R38 polymorphisms and oral diseases in Thais: a cross-sectional study.
TAS2R38 polymorphisms and oral diseases in Thais: a cross-sectional study.
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DOI：
10.1186/s12903-022-02043-2
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发表时间：
2022-01-28
期刊：
影响因子：
2.9
通讯作者：
Coldwell SE
中科院分区：
文献类型：
--
作者：
Khimsuksri S;Paphangkorakit J;Pitiphat W;Coldwell SE
TAS 2 R38苦味受体基因中49、262和296位的多态性导致两种常见的遗传单倍型PAV和AVI，以所产生的氨基酸取代命名。TAS 2 R38基因型与儿童龋齿风险相关。本研究旨在确定泰国人中TAS 2 R38多态性，并探讨基因型与口腔疾病之间的任何关联。在泰国孔敬大学牙科医院寻求治疗的患者被招募参加这项研究。收集唾液用于DNA提取和基因分型。患者完成问卷调查，收集人口统计学变量和评估口腔自我护理行为。校准牙医进行检查，包括牙周图表和记录腐烂，缺失和填充牙齿（DMFT）。共有250例患者（19-75岁）入组研究（116例男性）。PAV/PAV（46.0%）、PAV/AVI（42.4%）和AVI/AVI（11.6%）。记录238名参与者的DMFT和牙周状况。三个二倍体组在年龄、性别、社会经济指标、口腔自我护理和牙齿数量方面相似。与PAV/PAV相比，AVI/AVI和PAV/AVI中患牙周病（定义为至少一个部位的探测深度≥ 5 mm）的几率较低。与PAV/PAV相比，PAV/AVI倾向于具有更少的DMFT，而AVI/AVI倾向于具有更多的DMFT，但这些趋势未达到统计学显著性。TAS 2 R38基因型的频率分布与其他亚洲人群报告的频率分布相似。AVI/AVI基因型与泰国牙科患者牙周病患病率降低相关，而TAS 2 R38基因型与该患者人群的龋齿患病率之间无显著相关性。
Polymorphisms at positions 49, 262, and 296 in the TAS2R38 bitter taste receptor gene result in two common genetic haplotypes, PAV and AVI, named for the resulting amino acid substitutions. TAS2R38 genotype has been previously associated with caries risk in children. This study aimed to identify TAS2R38 polymorphisms among Thais and to explore any association between genotype and oral diseases. Patients seeking care at Khon Kaen University Dental Hospital in Thailand were recruited to participate in the study. Saliva was collected for DNA extraction and genotyping. Patients completed a questionnaire to collect demographic variables and assess oral self-care behaviors. A calibrated dentist conducted an examination that included periodontal charting and recording of decayed, missing, and filled teeth (DMFT). A total of 250 patients (19–75 years) were enrolled in the study (116 males). Two haplotypes, PAV (67.2%) and AVI (32.8%) were found, resulting in 3 diplotypes; PAV/PAV (46.0%), PAV/AVI (42.4%) and AVI/AVI (11.6%). DMFT and periodontal status of 238 participants were recorded. The three diplotype groups were similar in age, sex, socio-economic indicators, oral self-care, and number of teeth. The odds of having periodontal disease, defined as at least one site with probing depth ≥ 5 mm, were lower in AVI/AVI and PAV/AVI compared with PAV/PAV. PAV/AVI tended to have less DMFT, while AVI/AVI tended to have more DMFT compared with PAV/PAV, however these trends did not reach statistical significance. The frequency distribution of TAS2R38 genotypes was similar to that reported for other Asian populations. AVI/AVI genotype was associated with decreased prevalence of periodontal disease among Thai dental patients, whereas there was no significant association between TAS2R38 genotype and prevalence of tooth decay in this patient population.
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影响因子：
4.6
作者：
Risso, Davide S.;Mezzavilla, Massimo;Drayna, Dennis
通讯作者：
Drayna, Dennis
影响因子：
4.2
作者：
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通讯作者：
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DOI：
10.1002/ajpa.1330120314
发表时间：
1954-09-01
期刊：
AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY-NEW SERIES
影响因子：
--
作者：
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通讯作者：
Sringam, Sommai
影响因子：
9.2
作者：
Bufe, B;Breslin, PAS;Meyerhof, W
通讯作者：
Meyerhof, W
影响因子：
3.7
作者：
Latorre R;Huynh J;Mazzoni M;Gupta A;Bonora E;Clavenzani P;Chang L;Mayer EA;De Giorgio R;Sternini C
通讯作者：
Sternini C