Advances in Integrative Nanomedicine for Improving Infectious Disease Treatment in Public Health.
Advances in Integrative Nanomedicine for Improving Infectious Disease Treatment in Public Health.
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DOI：
10.1016/j.eujim.2012.11.002
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发表时间：
2013-04-01
影响因子：
2.5
通讯作者：
Brooks AJ
中科院分区：
文献类型：
--
作者：
Bell IR;Schwartz GE;Boyer NN;Koithan M;Brooks AJ
传染病给全世界的公共卫生带来挑战。一种新兴的治疗传染病的综合方法是使用纳米颗粒（NP）形式的传统和替代药物。纳米药物递送方法的优点包括更好的疾病靶向，特别是对于细胞内病原体，穿过膜并进入细胞的能力，更长的药物作用持续时间，减少副作用，以及从较低剂量节省成本。我们检索Pubmed的英文文章，关键词与纳米粒子和纳米医学。纳米技术术语还与药物输送、传染病、草药、抗氧化剂、顺势疗法和适应性等关键词相结合。纳米颗粒是非常小的材料物质形式，在至少一个维度上测量为沿着1-100纳米。与本体形式相比，NPs的大的表面积与体积比赋予增加的反应性和吸附能力，具有独特的电磁、化学、生物和量子特性。纳米技术使用天然植物制剂进行绿色制造毒性较小的纳米颗粒。纳米颗粒草药和营养品可以通过提高生物利用度和抗氧化剂，抗氧化剂和免疫调节作用治疗感染。最近的研究表明，顺势疗法药物可能含有源和/或二氧化硅纳米粒子，因为他们的传统制造工艺。顺势疗法作为纳米医学的一种形式，在治疗流行性传染病，包括疟疾、钩端螺旋体病和艾滋病毒/艾滋病以及急性上呼吸道感染方面具有很好的历史。宿主复杂网络的适应性变化是影响的基础。纳米医学是综合性的，将现代技术与天然产品相结合，以减少毒性并支持免疫功能。使用替代医学系统的传统药物的纳米医学可以促进传染病综合公共卫生方法的进步。
Infectious diseases present public health challenges worldwide. An emerging integrative approach to treating infectious diseases is using nanoparticle (NP) forms of traditional and alternative medicines. Advantages of nanomedicine delivery methods include better disease targeting, especially for intracellular pathogens, ability to cross membranes and enter cells, longer duration drug action, reduced side effects, and cost savings from lower doses. We searched Pubmed articles in English with keywords related to nanoparticles and nanomedicine. Nanotechnology terms were also combined with keywords for drug delivery, infectious diseases, herbs, antioxidants, homeopathy, and adaptation. NPs are very small forms of material substances, measuring 1–100 nanometers along at least one dimension. Compared with bulk forms, NPs’ large ratio of surface-area-to-volume confers increased reactivity and adsorptive capacity, with unique electromagnetic, chemical, biological, and quantum properties. Nanotechnology uses natural botanical agents for green manufacturing of less toxic NPs. Nanoparticle herbs and nutriceuticals can treat infections via improved bioavailability and antiinflammatory, antioxidant, and immunomodulatory effects. Recent studies demonstrate that homeopathic medicines may contain source and/or silica nanoparticles because of their traditional manufacturing processes. Homeopathy, as a form of nanomedicine, has a promising history of treating epidemic infectious diseases, including malaria, leptospirosis and HIV/AIDS, in addition to acute upper respiratory infections. Adaptive changes in the host’s complex networks underlie effects. Nanomedicine is integrative, blending modern technology with natural products to reduce toxicity and support immune function. Nanomedicine using traditional agents from alternative systems of medicine can facilitate progress in integrative public health approaches to infectious diseases.
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DOI：
10.1158/1940-6207.capr-10-0006
发表时间：
2011-08
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Bansal SS;Goel M;Aqil F;Vadhanam MV;Gupta RC
通讯作者：
Gupta RC
影响因子：
--
作者：
Bell, IR;Caspi, O;Weil, A
通讯作者：
Weil, A
影响因子：
--
作者：
Al-Sadoon, Mohamed K.;Abdel-Maksoud, Mostafa A.;Badr, Gamal
通讯作者：
Badr, Gamal
影响因子：
2.9
作者：
ANTELMAN, SM;CAGGIULA, AR;BARRY, H
通讯作者：
BARRY, H
影响因子：
11
作者：
Antelman, SM;Levine, J;Gershon, S
通讯作者：
Gershon, S