The search for genetic variants and epigenetics related to asthma.

The search for genetic variants and epigenetics related to asthma.
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DOI:
10.4168/aair.2011.3.4.236
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发表时间:
2011-10
期刊:
Allergy, asthma & immunology research
影响因子:
--
通讯作者:
Park CS
Park CS
中科院分区:
其他
文献类型:
--
作者:
Lee SH;Park JS;Park CS

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在过去的二十年里,人们进行了大量的基因研究,以确定导致哮喘风险的基因变异。几种类型的遗传和基因组方法,包括连锁分析,候选基因单核苷酸多态性研究和全基因组关联研究已被应用。在这篇综述文章中,总结了这些方法的结果,并讨论了它们的局限性。此外,应用即将到来的新的表观遗传学或基因组技术的观点,如拷贝数变异,介绍了增加我们对哮喘遗传学新组学方法的理解。
For the past two decades, a huge number of genetic studies have been conducted to identify the genetic variants responsible for asthma risk. Several types of genetic and genomic approaches, including linkage analysis, candidate gene single nucleotide polymorphism studies, and whole genome-wide association studies have been applied. In this review article, the results of these approaches are summarized, and their limitations are discussed. Additionally, perspectives for applying upcoming new epigenetic or genomic technologies, such as copy number variation, are introduced to increase our understanding of new omic approaches to asthma genetics.
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