The search for genetic variants and epigenetics related to asthma.
The search for genetic variants and epigenetics related to asthma.
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DOI:
10.4168/aair.2011.3.4.236
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发表时间:
2011-10
期刊:
影响因子:
--
通讯作者:
Park CS
中科院分区:
文献类型:
--
作者:
Lee SH;Park JS;Park CS
For the past two decades, a huge number of genetic studies have been conducted to identify the genetic variants responsible for asthma risk. Several types of genetic and genomic approaches, including linkage analysis, candidate gene single nucleotide polymorphism studies, and whole genome-wide association studies have been applied. In this review article, the results of these approaches are summarized, and their limitations are discussed. Additionally, perspectives for applying upcoming new epigenetic or genomic technologies, such as copy number variation, are introduced to increase our understanding of new omic approaches to asthma genetics.
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