Non-classical steroid signalling through SF-1 responsive genes: a key mechanism in environmental endocrine disruption, cancer, and aging

众所周知，塑料、化妆品和阻燃剂中普遍存在的模仿天然激素的人造化学品干扰内分泌，会导致模式生物和野生动物发育缺陷，对人类健康也有重大风险。这种风险随着人口密度的增加和对水循环的依赖而增加。目前评估这类物质的测试使用了过于简化的激素作用模式，严重低估了内分泌紊乱的风险。这一提议将产生关于这些物质如何在人体内或对野生动物起作用的新知识，并为新的更灵敏的环境监测方法奠定基础。

Endocrine disruption by pervasive manmade chemicals, which mimic natural hormones, and are found in plastics, cosmetics, and fire retardants, is known to cause developmental defects in model organisms and wildlife, with substantial risk also to human health. This risk increases with increasing population density and dependence on water recycling. Current tests to assess such substances use oversimplified modes of hormone action and grossly underestimate the risk of endocrine disruption. This proposal will yield new knowledge about how such substances act in the body, or on wildlife, and form the basis for new more sensitive methods of environmental monitoring.